KEAP1 - kelch like ECH associated protein 1 Gene

Also Known as INrf2; KLHL19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9817

About KEAP1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,486,125-10,503,356 (from NCBI)

This gene has 10 transcripts (splice variants), 189 orthologues, 54 paralogues and is associated with 94 phenotypes. Ubiquitous expression in kidney (RPKM 10.4), prostate (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

KEAP1 Products (6)

mRNA	Protein	Name
XM_011528452.2	XP_011526754.1	kelch-like ECH-associated protein 1 isoform X1
NM_203500.2	NP_987096.1	kelch-like ECH-associated protein 1
XM_005260174.2	XP_005260231.1	kelch-like ECH-associated protein 1 isoform X1
XM_005260173.2	XP_005260230.1	kelch-like ECH-associated protein 1 isoform X1
NM_012289.4	NP_036421.2	kelch-like ECH-associated protein 1
XM_047439788.1	XP_047295744.1	kelch-like ECH-associated protein 1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17015834	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15601839	GOA
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	17015834	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	15572695	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	15601839	GOA
involved in negative regulation of response to oxidative stress	IDA IDA: Inferred from direct assay	15601839	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17015834	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15601839	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	20452972	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15572695	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	15601839	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15601839	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	20452972	GOA
located in midbody	IDA IDA: Inferred from direct assay	15166316	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KEAP1 Protein Structure

BTB

BACK

Kelch_1

0
100
200
300
400
500
624 a.a.

Protein Preferred Names	Protein Names
kelch-like ECH-associated protein 1	KEAP1 delta C cytosolic inhibitor of Nrf2 kelch-like family member 19 kelch-like protein 19

KEAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	KEAP1	Q14145	ATG5	Homo sapiens	A9UGY9	Validated Y2H	25416956
Intra	KEAP1	Q14145	GYPA	Homo sapiens	B8Q183	Y2H Array	25416956
Intra	KEAP1	Q14145	PTMA	Homo sapiens	P06454-2	Validated Y2H	25416956
Intra	KEAP1	Q14145	PTMA	Homo sapiens	P06454-2	Y2H Array	25416956
Intra	KEAP1	Q14145	KLHL3	Homo sapiens	Q8N4I8	Validated Y2H	25416956
Intra	KEAP1	Q14145	GPErik	Homo sapiens	Q14440	Y2H Array	25416956
Intra	KEAP1	Q14145	GPErik	Homo sapiens	Q14440	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	GPErik	Homo sapiens	Q14440	Validated Y2H	25416956
Intra	KEAP1	Q14145	RECK	Homo sapiens	Q6P9E2	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	RECK	Homo sapiens	Q6P9E2	Validated Y2H	32296183
Intra	KEAP1	Q14145	RECK	Homo sapiens	Q6P9E2	Validated Y2H	25416956
Intra	KEAP1	Q14145	OXR1	Homo sapiens	Q8N573-5	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	OXR1	Homo sapiens	Q8N573-5	Validated Y2H	25416956
Intra	KEAP1	Q14145	ATG5	Homo sapiens	Q9H1Y0	Validated Y2H	32296183
Intra	KEAP1	Q14145	ATG5	Homo sapiens	Q9H1Y0	Y2H Array	32296183
Intra	KEAP1	Q14145	ERICH5	Homo sapiens	Q6P6B1	Validated Y2H	32296183
Intra	KEAP1	Q14145	C2orf68	Homo sapiens	Q2NKX9	Validated Y2H	32296183
Intra	KEAP1	Q14145	PRKAG1	Homo sapiens	P54619	Validated Y2H	25416956
Intra	KEAP1	Q14145	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	KEAP1	Q14145	GPR151	Homo sapiens	Q8TDV0	Validated Y2H	32296183
Intra	KEAP1	Q14145	IQCC	Homo sapiens	Q4KMZ1	Validated Y2H	32296183
Intra	KEAP1	Q14145	PALB2	Homo sapiens	Q86YC2	Validated Y2H	32296183
Intra	KEAP1	Q14145	STAP2	Homo sapiens	Q9UGK3	Validated Y2H	32296183
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	37187359
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	ITC	18757741
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	16888629
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Tag CoIP	18757741
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	mRNA Display	31169361
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Pull Down	16888629
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Tag CoIP	31262713
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	X-Ray Diffraction	16888629
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Phage Display	39009827
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Y2H	21988832
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	SPR	31169361
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	19706542
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Pull Down	31169361
Intra	KEAP1	Q14145	NFE2L2	Homo sapiens	Q16236	Anti Bait CoIP	29792731
Intra	KEAP1	Q14145	ASTN1	Homo sapiens	O14525-2	Pull Down	31169361
Intra	KEAP1	Q14145	ASTN1	Homo sapiens	O14525-2	mRNA Display	31169361
Intra	KEAP1	Q14145	ASTN1	Homo sapiens	O14525-2	SPR	31169361
Intra	KEAP1	Q14145	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	32296183
Intra	KEAP1	Q14145	NIBAN2	Homo sapiens	Q96TA1	Anti Tag CoIP	31262713
Intra	KEAP1	Q14145	NIBAN2	Homo sapiens	Q96TA1	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	NFE2L1	Homo sapiens	Q14494	Phage Display	35044719
Intra	KEAP1	Q14145	NFE2L1	Homo sapiens	Q14494	FPS	35044719
Intra	KEAP1	Q14145	PLEC	Homo sapiens	Q15149	FPS	35044719
Intra	KEAP1	Q14145	PLEC	Homo sapiens	Q15149	Phage Display	35044719
Intra	KEAP1	Q14145	ITGB2	Homo sapiens	P05107	Y2H Array	32814053
Intra	KEAP1	Q14145	ITGB2	Homo sapiens	P05107	Y2H Pooling	32814053
Intra	KEAP1	Q14145	ITGB2	Homo sapiens	P05107	Validated Y2H	32814053
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Validated Y2H	25416956
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Pull Down	20452972
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20452972
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	39009827
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20173742
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Confocal	20452972
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	FPS	39009827
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	mRNA Display	31169361
Intra	KEAP1	Q14145	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	34591642
Intra	KEAP1	Q14145	WHRN	Homo sapiens	Q9P202	Validated Y2H	32296183
Intra	KEAP1	Q14145	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	KEAP1	Q14145	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	KEAP1	Q14145	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	KEAP1	Q14145	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	25416956
Intra	KEAP1	Q14145	FAM117B	Homo sapiens	Q6P1L5	Validated Y2H	32296183
Intra	KEAP1	Q14145	NUDT4	Homo sapiens	Q9NZJ9	Y2H Array	25416956
Cross	KEAP1	Q14145	Ikbkb	Mus musculus	O88351	Y2H	20600852
Intra	KEAP1	Q14145	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	KEAP1	Q14145	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	KEAP1	Q14145	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	KEAP1	Q14145	IFIH1	Homo sapiens	Q9BYX4	Validated Y2H	32296183
Intra	KEAP1	Q14145	GYPA	Homo sapiens	P02724	Y2H Array	31515488
Intra	KEAP1	Q14145	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	KEAP1	Q14145	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Validated Y2H	32296183
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Anti Tag CoIP	34591642
Intra	KEAP1	Q14145	DPP3	Homo sapiens	Q9NY33	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KEAP1	Q14145	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KEAP1	Q14145	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Anti Tag CoIP	21988832
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Confocal	21988832
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Y2H	21988832
Intra	KEAP1	Q14145	RELA	Homo sapiens	Q04206	Y2H Array	21988832
Intra	KEAP1	Q14145	TSC22D4	Homo sapiens	Q9Y3Q8	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	ZSCAN32	Homo sapiens	Q9NX65	Validated Y2H	25416956
Intra	KEAP1	Q14145	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	KEAP1	Q14145	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	31515488
Intra	KEAP1	Q14145	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	KEAP1	Q14145	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	KEAP1	Q14145	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Validated Y2H	25416956
Intra	KEAP1	Q14145	ETF1	Homo sapiens	P62495	Y2H Array	25416956
Intra	KEAP1	Q14145	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Validated Y2H	32296183
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Y2H Array	31515488
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Y2H Prey Pooling	25416956
Intra	KEAP1	Q14145	WDR83	Homo sapiens	Q9BRX9	Validated Y2H	25416956
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Y2H Array	31515488
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Y2H Prey Pooling	32296183
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Y2H Array	25416956
Intra	KEAP1	Q14145	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	19615732
Intra	KEAP1	Q14145	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	20600852
Intra	KEAP1	Q14145	IKBKB	Homo sapiens	O14920	Pull Down	20600852
Intra	KEAP1	Q14145	IKBKB	Homo sapiens	O14920	Anti Bait CoIP	20600852
Intra	KEAP1	Q14145	KLHL3	Homo sapiens	Q9UH77	Validated Y2H	32296183
Intra	KEAP1	Q14145	MCMBP	Homo sapiens	Q9BTE3-2	Validated Y2H	32296183
Intra	KEAP1	Q14145	MAPKBP1	Homo sapiens	O60336	Validated Y2H	25416956
Intra	KEAP1	Q14145	MAPKBP1	Homo sapiens	O60336	Y2H Array	25416956
Intra	KEAP1	Q14145	MAPKBP1	Homo sapiens	O60336	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KEAP1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P75897	KEAP1 Protein, Human (sf9)	Q14145 (Q2-C624)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P75899	KEAP1 Protein, Human (sf9, His-GST)	Q14145 (Q2-C624)	≥ 90%, as determined by reducing SDS-PAGE.

KEAP1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80732	Keap1 Antibody (YA324)	WB, IHC-P	Human, Mouse
HY-P80732A	Keap1 Antibody (YA324)(PBS only)	WB, IHC-P	Human, Mouse
HY-P84564	Keap1 Antibody (YA4261)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P84564A	Keap1 Antibody (YA4261)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse
HY-P85866	Keap1 Antibody (YA5558)	WB, ICC/IF, ELISA	Human, Mouse, Rat, Dog,
HY-P86405	Keap1 Antibody (YA6097)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fumarase Deficiency	Fumaric Aciduria FMRD Fumarate Hydratase Deficiency Deficiency, Fumarase
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Penis Carcinoma In Situ	Carcinoma In Situ Of Penis Bowen'S Disease Of Penis Grade Iii Squamous Intraepithelial Lesion Of Penis Penile Intraepithelial Neoplasia Grade Iii Queyrat'S Erythroplasia Erythroplasia Of Queyrat Pin - [Penile Intraepithelial Neoplasia]
Diabetes Mellitus	Diabetes
Microphthalmia, Isolated 1	Isolated Microphthalmia 1 MCOP1 Mcop Anophthalmia, Clinical, Isolated Microphthalmos, Autosomal Recessive
Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors	Euthyroid Goiter MNG1 Simple Goiter Goiter Euthyroid Goiter, Nontoxic, With Intrathyroidal Calcification Multinodular Goiter, Adolescent Familial Multinodular Goiter Fmng Familial Mng Familial Multinodular Goiter Syndrome Goiter Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors Goiter Nontoxic With Intrathyroidal Calcification Goiter Non-Toxic With Intrathyroidal Calcification Multinodular Goiter Adolescent Goiter, Multinodular, Type 1, With/Without Sertoli-Leydig Cell Tumors Endemic Goiter
Trichothiodystrophy 4, Nonphotosensitive	Amish Brittle Hair Brain Syndrome TTD4 Trichothiodystrophy, Nonphotosensitive 1 Hair-Brain Syndrome Bids Syndrome Ttdn1 Abhs Pollitt Syndrome Trichothiodystrophy-Neurocutaneous Syndrome Nonphotosensitive Trichothiodystrophy 4 Trichorrhexis Nodosa Syndrome Trichothiodystrophy 4, Non-Photosensitive Trichothiodystrophy Non-Photosensitive 1
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Large Cell Carcinoma With Rhabdoid Phenotype	Large Cell Lung Carcinoma With Rhabdoid Phenotype

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-W012382	N-Acetyl-L-tyrosine		99.48%	Unkown

Clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-N0005	Curcumin		98.84%	Phase 4
HY-13755	Sulforaphane		99.75%	Phase 4
HY-N1437	Hydroxycitric acid		99.95%	Phase 2
HY-159641	VVD-130037	Activator	99.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (130)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-100218A	RSL3		99.87%	Unkown
HY-112675	4-Octyl itaconate	Activator	99.92%	Unkown
HY-19543	Brusatol		99.94%	Unkown
HY-101140	KI696		99.26%	Unkown
HY-110258	ML334	Activator	99.76%	Unkown
HY-134205A	CBR-470-1	Activator	98.02%	Unkown
HY-113298	Citraconic acid	Inhibitor	99.08%	Unkown
HY-N0147	Rutaecarpine		99.77%	Unkown
HY-N0005R	Curcumin (Standard)		98.01%	Unkown
HY-N0806	Sweroside		99.76%	Unkown
HY-P2048	MOTS-c (human)		99.90%	Unkown
HY-13755A	(R)-Sulforaphane		99.95%	Unkown
HY-P2048A	MOTS-c(human) acetate	Activator	99.74%	Unkown
HY-N0353	Curdione	Inhibitor	99.80%	Unkown
HY-111126	K67	Inhibitor	98.26%	Unkown
HY-N0493	Pectolinarigenin		99.98%	Unkown
HY-113162	Bovinic acid		≥99.0%	Unkown
HY-149508	Nrf2-IN-3		98.10%	Unkown
HY-120371	CPUY192018	Inhibitor	98.90%	Unkown
HY-145879	Nrf2 activator-2	Activator	99.20%	Unkown
HY-W009731	Dibenzoylmethane	Activator	98.0%	Unkown
HY-153873	MSU38225		99.94%	Unkown
HY-N0260	Epmedin C		99.47%	Unkown
HY-110275	RA839	Inhibitor	98.54%	Unkown
HY-103435	Vialinin A		99.90%	Unkown
HY-131592	Tricetin		99.88%	Unkown
HY-B0854	Mancozeb		85.50%	Unkown
HY-N0005S	Curcumin-d6		99.78%	Unkown
HY-N0008	Orcinol glucoside		98.92%	Unkown
HY-101140A	KI696 isomer		98.44%	Unkown
HY-171705	KMS99220		99.48%	Unkown
HY-W338584	Hydroxycitric acid tripotassium		98.0%	Unkown
HY-100218C	(1R,3R)-RSL3	Control	99.05%	Unkown
HY-139047	SW157765	Inhibitor	98.08%	Unkown
HY-149010	NXPZ-2	Inhibitor	98.55%	Unkown
HY-151362	Keap1-Nrf2-IN-14	Inhibitor	98.08%	Unkown
HY-169766	VVD 065	Degrader	99.71%	Unkown
HY-160876	BC-1901S	Activator	99.81%	Unkown
HY-P1328	TAT-14	Activator	99.71%	Unkown
HY-162152	biKEAP1	Inhibitor	99.44%	Unkown
HY-110258B	(R,S,R)-ML334	Control	98.57%	Unkown
HY-P10530	Nrf2 (69-84)		95.25%	Unkown
HY-W012382S	N-Acetyl-L-tyrosine-d3		98.44%	Unkown
HY-W017187	2-tert-Butyl-1,4-benzoquinone		99.34%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-121523	MIND4-17	Activator	99.05%	Unkown
HY-150579	Keap1-Nrf2-IN-13	Inhibitor	96.77%	Unkown
HY-173444	HDAC11-IN-3		99.70%	Unkown
HY-124834	Nrf2 activator-10		98.65%	Unkown
HY-146577	Keap1-Nrf2-IN-7	Inhibitor	99.82%	Unkown
HY-P5909	Keap1-Nrf2 probe		98.75%	Unkown
HY-P5909F	FITC-labeled Keap1-Nrf2 probe		98.57%	Unkown
HY-RS07231	Keap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-122054	BPK-29		99.4%	Unkown
HY-122054A	BPK-29 hydrochloride	Inhibitor	99.19%	Unkown
HY-178054	LMDP10	Activator	99.91%	Unkown
HY-139620	MS83	Degrader	/	Unkown
HY-139620A	MS83 epimer 1		98.36%	Unkown
HY-113510	9(S)-HOTrE		99.9%	Unkown
HY-N8160	Dehydrocurdione		97%	Unkown
HY-RS07230	KEAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112675R	4-Octyl itaconate (Standard)	Activator	/	Unkown
HY-113162R	Bovinic acid (Standard)		/	Unkown
HY-124941	7-Deacetylgedunin	Activator	/	Unkown
HY-139862	Keap1-Nrf2-IN-3	Inhibitor	/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib	Degrader	/	Unkown
HY-141439	TBE 31		/	Unkown
HY-143892	Keap1-Nrf2-IN-5	Inhibitor	/	Unkown
HY-143893	Keap1-Nrf2-IN-6	Inhibitor	/	Unkown
HY-144099	Keap1-Nrf2-IN-4		/	Unkown
HY-146578	Keap1-Nrf2-IN-8	Inhibitor	/	Unkown
HY-147924	Keap1-Nrf2-IN-11	Inhibitor	/	Unkown
HY-149245	Keap1-Nrf2-IN-15	Inhibitor	/	Unkown
HY-150578	Keap1-Nrf2-IN-12	Inhibitor	/	Unkown
HY-155997	Anti-inflammatory agent 56	Inhibitor	/	Unkown
HY-156065	S217879		/	Unkown
HY-157928	Keap1-Nrf2-IN-18	Inhibitor	/	Unkown
HY-157929	Keap1-Nrf2-IN-19	Inhibitor	/	Unkown
HY-159495	Keap1-Nrf2-IN-21		/	Unkown
HY-161643	S21-1011		/	Unkown
HY-168065	Keap1-Nrf2-IN-22	Inhibitor	/	Unkown
HY-168161	Keap1-Nrf2-IN-23	Inhibitor	/	Unkown
HY-168526	Keap1-Nrf2-IN-24	Inhibitor	/	Unkown
HY-168640	RIP3 activator 1		/	Unkown
HY-168709	Nrf2 activator 18	Activator	/	Unkown
HY-168922	Keap1-Nrf2-IN-25	Inhibitor	/	Unkown
HY-169315	Nrf2 activator 17	Activator	/	Unkown
HY-170301	Keap1-IN-1	Inhibitor	/	Unkown
HY-170761	KEAP1-NRF2 PPI-IN-1	Inhibitor	/	Unkown
HY-171035	PRL-295	Inhibitor	/	Unkown
HY-172598	SG16	Inhibitor	/	Unkown
HY-173039	α-Tubulin polymerization-IN-1		/	Unkown
HY-173181	Anticonvulsant agent 10	Inhibitor	/	Unkown
HY-173187	Keap1-Nrf2-IN-27	Inhibitor	/	Unkown
HY-174395	CD-10		/	Unkown
HY-175217	Nrf2 activator-20	Activator	/	Unkown
HY-175548	Nrf2 activator-21		/	Unkown
HY-175833	NF-κB-IN-20		/	Unkown
HY-176146	Keap1/Nrf2/ARE activator 1	Activator	/	Unkown
HY-178873	PROTAC K-Ras Degrader-7	Degrader	/	Unkown
HY-179398	Keap1-Nrf2-IN-29	Inhibitor	/	Unkown
HY-180112	SH543		/	Unkown
HY-180155	Keap1/Nrf2/ARE activator 2		/	Unkown
HY-181818	4,5-Dehydro-6-oxoallosecurinine		/	Unkown
HY-181887	Nrf2 activator-23		/	Unkown
HY-181907	NBE5		/	Unkown
HY-181908	5-Norbornene-2-methylamine-C10-NH2		/	Unkown
HY-183353	Nrf2 activator-25		/	Unkown
HY-184204	Keap1-p-p62-IN-1		/	Unkown
HY-184698	Nrf2/HO-1 activator 4		/	Unkown
HY-184761	Keap1-Nrf2-IN-30		/	Unkown
HY-N10313	Dehydrobruceine B		/	Unkown
HY-N17317	Isostrictiniin		/	Unkown
HY-N17603	Ginnalin A	Activator	/	Unkown
HY-N19738	Obtusaquinone		/	Unkown
HY-P1328A	TAT-14 TFA	Activator	/	Unkown
HY-P5480	Keap1-Nrf2-IN-16		/	Unkown
HY-RS07232	Keap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W701218	Sulforaphane-d8		/	Unkown
HY-112675S	4-Octyl itaconate-13C5-1		/	Unkown
HY-147548	Keap1-Nrf2-IN-10	Inhibitor	/	Unkown
HY-162096	Keap1-Nrf2-IN-17	Inhibitor	/	Unkown
HY-174287	Keap1-IN-2	Inhibitor	/	Unkown
HY-182927	KLHL12 ligand-1		/	Unkown
HY-183448	ETMTC		/	Unkown
HY-184788	2-Hydroxy-5-(2-nitrovinyl)benzoic acid		/	Unkown
HY-N0005S1	Curcumin-d3		/	Unkown
HY-N0493R	Pectolinarigenin (Standard)		/	Unkown
HY-N11231	Fucoxanthinol		/	Unkown
HY-W505984	TPNA10168	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KEAP1	MGD	MGI:1858732
Felis catus	KEAP1	VGNC	VGNC:63076
Macaca mulatta	KEAP1	VGNC	VGNC:73891
Canis familiaris	KEAP1	VGNC	VGNC:42332
Rattus norvegicus	KEAP1	RGD	RGD:621619
Bos taurus	KEAP1	VGNC	VGNC:30537
Others	KEAP1	NCBI