GPR
GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 47295-77-2
- Formel: C13H24N6O4
- Molecular Weight:328.37
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Alle Caspase Isoform-spezifische Produkte anzeigen
More
Biologische Aktivität
Beschreibung
In Vitro
GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1].
GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1].
GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1].
GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:p53-positive cells
-
Concentration:50 μM
-
Incubation Time:3 days
-
Result:Inhibited Ah-induced increase in numbers of p53-positive neurons.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS. Nr. 47295-77-2
-
Molecular Weight 328.37
-
Formel C13H24N6O4
-
Sequence Shortening
GPR
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)