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Art. -Nr.: HY-118273

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IPS-05002

IPS-05002 is an α5β1 antagonist. IPS-05002 can inhibit VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration, and also suppresses tubular network formation. IPS-05002 can upregulate IKB-β, XRCC4, and downregulate Cdc6 in VEGF-induced HUVECs. IPS-05002 can be used for the study of tumor angiogenesis.

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CAS. Nr.: 1185036-77-4
Formel: C₂₂H₁₉FN₄O₂S
Molecular Weight:422.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

IPS-05002 Chemical Structure

CAS. Nr.: 1185036-77-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

α5β1

Alle Integrin Isoform-spezifische Produkte anzeigen :

In Vitro

IPS-05002 (0.78-200 μM, 1 h) inhibits the binding of integrin α5β1 to fibronectin in a dose-dependent manner^[1].
IPS-05002 (72 h) markedly suppresses the proliferation and adhesion of HUVEC (IC50 = 20.5 μM)^[1].
IPS-05002 (6.25-1700 μM, 0-24 h) significantly perturbs VEGF-induced HUVEC migration in a dose and time-dependent fashion (IC₅₀ = 15.52 μM)^[1].
IPS-05002 (3-50 μM, 90 min) dose-dependently inhibits the adhesion of HUVECs to Matrigel^[1].
IPS-05002 (24 h) upregulates VEGF-induced IκB-β and XRCC4 in HUVECs and downregulates Cdc6 protein expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

human umbilical vein endothelial cell (HUVEC)
Concentration:

6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM, 106.25 μM, 212.5 μM, 425 μM, 850 μM, 1700 μM
Incubation Time:

0 h, 12 h, 24 h
Result:

Significantly perturbed VEGF-induced HUVEC migration compared with GRGDSP-treated control group in a dose and time-dependent fashion.

Chemical Information

CAS. Nr. 1185036-77-4
Molecular Weight 422.48
Formel C₂₂H₁₉FN₄O₂S
SMILES

OC1=C(C2NCCC3=C2NC4=CC=CC=C43)C(N(C(N1)=S)CC5=CC=C(C=C5)F)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kim, et al. Anti-angiogenic mechanism of IPS-05002, a novel antagonist against integrin a5β1, determined by ProteoChip-based antibody array. BioChip Journal, 10(3), 174–181.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
Chemical Information
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IPS-05002

Alle Integrin Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

IPS-05002 Related Classifications

HY-118273 Related Classifications