Art. -Nr.: HY-N4157

Isopteropodine

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Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research.

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Reinheit: 99.13%
CAS. Nr.: 5171-37-9
Formel: C₂₁H₂₄N₂O₄
Molecular Weight:368.43

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Isopteropodine Chemical Structure

CAS. Nr.: 5171-37-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

mAChR1

5-HT₂ Receptor

Alle mAChR Isoform-spezifische Produkte anzeigen :

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Isopteropodine (1-30 μM) can enhance the Ca²⁺-activated Cl^- currents induced by acetylcholine and 5-HT in a concentration-dependent manner in Xenopus oocytes expressing rat cortical total RNA, without significant effect on the currents mediated by metabotropic glutamate receptors (mGlu_1/5) and ionotropic receptors (NMDA, kainic acid, glycine)^[1].
Isopteropodine (353-679 μM; 24 h) has antibacterial activity against Staphylococcus aureus and Bacillus subtilis in vitro, with minimum inhibitory concentrations (MIC) of 408 μM and 679 μM, respectively, without inhibitory effect on fungi^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 5171-37-9

Appearance Solid

Molecular Weight 368.43

Formel C₂₁H₂₄N₂O₄

Color White to off-white

SMILES

O=C(C1=CO[C@@H](C)[C@]([C@]1([H])C[C@]23[H])([H])CN2CC[C@]43C(NC5=C4C=CC=C5)=O)OC

Structure Classification

Terpenoids

Iridoids

Initial Source

Plants

Rubiaceae

Uncaria rhynchophylla (Miq.) Miq. ex Havil.

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (135.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7142 mL

13.5711 mL

27.1422 mL

5 mM

0.5428 mL

2.7142 mL

5.4284 mL

10 mM

0.2714 mL

1.3571 mL

2.7142 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:

To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.79 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg

Animal Weight (Per Animal) Animal Weight (Per Animal)
g

Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL

Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

%
+

+
%
Tween-80 + +

%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact
MedChemExpress (MCE) .

Tel: 609-228-6898
E-mail: [email protected]
Technical Support: [email protected]

Method for preparing in vivo working solution for animal experiments:
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Saline .

Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)

SDS (479 KB)

English - EN (479 KB)

Français - FR (479 KB)

Deutsch - DE (479 KB)

Norwegian - NO (479 KB)

Español - ES (479 KB)

Swedish - SV (479 KB)

Italian - IT (479 KB)

Korean - KR (479 KB)

Portuguese - PT (479 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Kang TH, et al. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte. Eur J Pharmacol. 2002 May 24;444(1-2):39-45. [Content Brief]

[2]. García R, et al. Antimicrobial activity of isopteropodine. Z Naturforsch C J Biosci. 2005 May-Jun;60(5-6):385-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg

DMSO 1 mM 2.7142 mL 13.5711 mL 27.1422 mL 67.8555 mL

5 mM 0.5428 mL 2.7142 mL 5.4284 mL 13.5711 mL

10 mM 0.2714 mL 1.3571 mL 2.7142 mL 6.7855 mL

15 mM 0.1809 mL 0.9047 mL 1.8095 mL 4.5237 mL

20 mM 0.1357 mL 0.6786 mL 1.3571 mL 3.3928 mL

25 mM 0.1086 mL 0.5428 mL 1.0857 mL 2.7142 mL

30 mM 0.0905 mL 0.4524 mL 0.9047 mL 2.2618 mL

40 mM 0.0679 mL 0.3393 mL 0.6786 mL 1.6964 mL

50 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3571 mL

60 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1309 mL

80 mM 0.0339 mL 0.1696 mL 0.3393 mL 0.8482 mL

100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6786 mL

Isopteropodine Related Classifications

HY-N4157 Related Classifications

GPCR/G Protein Anti-infection Neuronal Signaling

mAChR Bacterial 5-HT Receptor

Disease Areas

Infection Neurological, Eye or Ear Disease Metabolic or Endocrine Disease

Neurodegenerative Disease Lipid Metabolism Bacterial Infection Depression

Alzheimer's Disease Obesity

Natürliche Produkte

Plants Terpenoids

Rubiaceae Iridoids

Uncaria rhynchophylla (Miq.) Miq. ex Havil.

Reference Standards

Natural Product Standards

Terpenoids

Neurological Disease

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Keywords

Isopteropodine
5171-37-9
mAChR
Bacterial
5-HT Receptor
heteroyohimbine-type
oxindole
alkaloid
Uncaria
tomentosa
Inhibitor
inhibitor
inhibit

Your Recently Viewed Products

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7142 mL	13.5711 mL	27.1422 mL	67.8555 mL
5 mM	0.5428 mL	2.7142 mL	5.4284 mL	13.5711 mL
10 mM	0.2714 mL	1.3571 mL	2.7142 mL	6.7855 mL
15 mM	0.1809 mL	0.9047 mL	1.8095 mL	4.5237 mL
20 mM	0.1357 mL	0.6786 mL	1.3571 mL	3.3928 mL
25 mM	0.1086 mL	0.5428 mL	1.0857 mL	2.7142 mL
30 mM	0.0905 mL	0.4524 mL	0.9047 mL	2.2618 mL
40 mM	0.0679 mL	0.3393 mL	0.6786 mL	1.6964 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.3571 mL
60 mM	0.0452 mL	0.2262 mL	0.4524 mL	1.1309 mL
80 mM	0.0339 mL	0.1696 mL	0.3393 mL	0.8482 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.6786 mL

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Alle mAChR Isoform-spezifische Produkte anzeigen

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Isopteropodine Related Classifications

HY-N4157 Related Classifications