Art. -Nr.: HY-156371

MIPS-21335

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Based on 1 Customer Validation

MIPS-21335 is a PI3KC2α inhibitor with an IC₅₀ of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ, with IC₅₀ values of 43, 140, 386 and 742 nM, respectively. MIPS-21335 has antithrombotic effect. MIPS-21335 can be used for the researches of cardiovascular disease and metabolic disease, such as thrombosis and hyperlipidemia.

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Reinheit: 99.61%
CAS. Nr.: 2569296-51-9
Formel: C₂₄H₂₁N₇O₅
Molecular Weight:487.47

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

MIPS-21335 Chemical Structure

CAS. Nr.: 2569296-51-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

PI3KC2α

7 nM (IC₅₀)

PI3KC2β

43 nM (IC₅₀)

p110α

140 nM (IC₅₀)

p110β

386 nM (IC₅₀)

p110δ

742 nM (IC₅₀)

Alle PI3K Isoform-spezifische Produkte anzeigen :

In Vitro

MIPS-21335 (10 μM, 10 mins) impairs platelet-dependent thrombus growth on a collagen surface in blood^[1].
MIPS-21335 (0.1-10 μM, 10 mins) reduces thrombosis in blood isolated from hypercholesterolemic mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MIPS-21335 (1 mg/kg, i.v., 10 mins before tail transection) markedly delays and ultimately prevents thrombosis in thrombosis mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Thrombosis mice models^[1]
Dosage:

1 mg/kg
Administration:

Intravenously injection, 10 mins before tail transection
Result:

Showed smaller fibrin-rich thrombi with very few platelets.
Had no impact on bleeding time.

Chemical Information

CAS. Nr. 2569296-51-9
Appearance Solid
Molecular Weight 487.47
Formel C₂₄H₂₁N₇O₅
Color Off-white to light yellow
SMILES

COC1=C2N=C(N3CCN=C3C2=CC=C1OCC4=CC([N+]([O-])=O)=CC=C4)NC(C5=CN=C(C=C5)N)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (51.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0514 mL

10.2570 mL

20.5141 mL

5 mM

0.4103 mL

2.0514 mL

4.1028 mL

10 mM

0.2051 mL

1.0257 mL

2.0514 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Selvadurai MV, et al. Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation. Sci Transl Med. 2020 Jul 22;12(553):eaar8430. [Content Brief]

[2]. Setiabakti NM, et al. PI3KC2α inhibition is antithrombotic in blood from hypercholesterolemic mice. J Thromb Haemost. 2024 Jan;22(1):249-254. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0514 mL	10.2570 mL	20.5141 mL	51.2852 mL
	5 mM	0.4103 mL	2.0514 mL	4.1028 mL	10.2570 mL
	10 mM	0.2051 mL	1.0257 mL	2.0514 mL	5.1285 mL
	15 mM	0.1368 mL	0.6838 mL	1.3676 mL	3.4190 mL
	20 mM	0.1026 mL	0.5129 mL	1.0257 mL	2.5643 mL
	25 mM	0.0821 mL	0.4103 mL	0.8206 mL	2.0514 mL
	30 mM	0.0684 mL	0.3419 mL	0.6838 mL	1.7095 mL
	40 mM	0.0513 mL	0.2564 mL	0.5129 mL	1.2821 mL
	50 mM	0.0410 mL	0.2051 mL	0.4103 mL	1.0257 mL

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MIPS-21335

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Alle PI3K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MIPS-21335 Related Classifications

Art. -Nr.: HY-156371