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Art. -Nr.: HY-145813

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MU1656

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies.

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CAS. Nr.: 2766698-38-6
Formel: C₃₂H₄₅N₇O₂
Molecular Weight:559.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MU1656 Chemical Structure

CAS. Nr.: 2766698-38-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies^[1].

IC₅₀ & Target^[1]

DOT1L

2 nM (IC₅₀)

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	EC₅₀	7.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
MV4-11	EC₅₀	1.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SK-N-MC	EC₅₀	8.8 μM Compound: (-)-53; MU1656	Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SU-DHL-5	EC₅₀	9 μM Compound: (-)-53; MU1656	Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]

Chemical Information

CAS. Nr. 2766698-38-6
Molecular Weight 559.75
Formel C₃₂H₄₅N₇O₂
SMILES

O[C@H]1[C@@H](C[C@@H]([C@H]1O)CN([C@H]2C[C@H](C2)CCC(NC3=C4)=NC3=CC=C4C(C)(C)C)C(C)C)C5=CC=C6N5N=CN=C6N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Khirsariya P, et, al. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Apr 14;65(7):5701-5723. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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MU1656

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MU1656 Related Classifications

HY-145813 Related Classifications