Pochonin D
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affects the homeostasis, folding and assembly processes of viral proteins, and reduces the replication capacity of viruses. Pochonin D is a copper ion carrier that can induce cuproptosis in triple-negative breast cancer cells by targeting PRDX1. Pochonin D reduces the infiltration of inflammatory cells, decreases the secretion of inflammatory cytokines such as TNF-α and IL-1β, and alleviates inflammatory responses. Pochonin D is a promising candidate for research on human rhinovirus (HRV) infection and cancer.
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- CAS. Nr.: 544712-82-5
- Formel: C18H19ClO5
- Molecular Weight:350.79
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Pochonin D (0.4-10 μM; 2 days) potently inhibits the replication and cytopathic effect (CPE) of HRV1B in HeLa cells, and shows no cytotoxicity within the tested concentration range[2]
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Pochonin D (0-40 μM; 1-7 days) significantly inhibits the proliferation and colony formation of TNBC cells (MDA-MB-231, 4T1, BT549, etc. cells), and is more sensitive to TNBC cells than other types of cancer cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (4-5 weeks of age)[2]
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Dosage:200 µg/kg
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Administration:i.p.; twice (1 hour pre-infection and 4 hours post-infection)
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Result:Reduced relative HRV1B NCR gene expression in lung tissue compared to vehicle-treated infected mice.
Decreased lung levels of CCL2, CXCL1, IL-1β, TNF-α, and IL-6 to near naïve control levels.
Significantly reduced BALF levels of CXCL1, IL-1β, TNF-α, and IL-6 compared to vehicle-treated infected mice.
Significantly lowered the number (1×104 cells) and percentage of myeloid-derived suppressor cells (MDSCs) in BALF compared to vehicle-treated infected mice.
Reduced lung edema, hemorrhage, and inflammatory cell infiltration, with lower histological scores compared to vehicle-treated infected mice.
Ameliorated tracheal airway cilia damage relative to vehicle-treated infected mice.
Chemical Information
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CAS. Nr. 544712-82-5
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Molecular Weight 350.79
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Formel C18H19ClO5
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SMILES
ClC1=C2C(C(O[C@@H](C/C=C/CC/C=C/C(C2)=O)C)=O)=C(C=C1O)O
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Synonyms
(+)-Pochonin D
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Structure Classification
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Initial Source
Humicola sp. FO-2942
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Choe H, et al. Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition. Org Lett. 2017;19(21):6004-6007. [Content Brief]
[2]. Song JH, et al. Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection. Biomol Ther (Seoul). 2018;26(6):576-583. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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