Art. -Nr.: HY-106449

Recoflavone

(Synonyms: DA-6034 free acid)

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Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(²⁺)]_i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury.

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Reinheit: 98.0%
CAS. Nr.: 203191-10-0
Formel: C₂₀H₁₈O₈
Molecular Weight:386.35

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Recoflavone Chemical Structure

CAS. Nr.: 203191-10-0

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Alle COX Isoform-spezifische Produkte anzeigen :

Alle ERK Isoform-spezifische Produkte anzeigen :

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

In Vitro

Recoflavone (100-250 µM; 24-48 h) increases mucin-like glycoprotein secretion in human corneal epithelial cells^[1].
Recoflavone (200 µM; 24 h) significantly increases the production of several mucins including MUC1, MUC2, MUC4, MUC5AC, MUC5B and MUC16 in human conjunctival epithelial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Recoflavone (3%; eye drops; single dose) significantly reduces corneal damage in a rabbit dry eye disease model^[1].
Recoflavone (30 mg/kg; oral administration; once every 12 hours; 3 days) exhibits protective effects in a rat small intestinal injury model^[2].
Recoflavone (30 mg/kg; oral gavage; twice daily; from day 7 to day 63) shows improvement effects in a mouse colitis-associated cancer model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male New Zealand White rabbits (2.5 kg) with desiccation-induced dry eye by keeping eyes open with a specula for 2 h^[1]
Dosage:

3 %
Administration:

Eye drops; single dose
Result:

Significantly decreased methylene blue permeability in the cornea compared to the vehicle-treated group, indicating prevention of desiccation-induced corneal damage.

Animal Model:

Sprague-Dawley rats aged 6 weeks old (250 g) treated Indomethacin (HY-14397) to induce small intestinal injury^[2]
Dosage:

30 mg/kg
Administration:

Oral administration; once every 12 hours; 3 days
Result:

Increased the ERK expression.
Had significantly lower intestinal permeability compared with the control group, while the inflammation scores and the extent of hemorrhagic lesions showed no statistically significant differences.

Animal Model:

C57BL/6 mice aged 10 weeks old (18-21 g) treated AOM (HY-111375) and DSS (HY-116282C) to induce colitis-associated cancer^[3]
Dosage:

30 mg/kg
Administration:

Oral gavage; twice daily; from day 7 to day 63
Result:

Reduced the number of colon tumors.
Ameliorated weight loss and colon shortening.
Enhanced apoptosis , and inhibited the expression of proliferation marker Ki-67, COX-2, and phospho-IKKα in colon tissue.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 203191-10-0
Appearance Solid
Molecular Weight 386.35
Formel C₂₀H₁₈O₈
Color Off-white to light yellow
SMILES

COC1=C2C(OC(C3=CC(OC)=C(OC)C=C3)=CC2=O)=CC(OCC(O)=O)=C1
Synonyms

DA-6034 free acid
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 40 mg/mL (103.53 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5883 mL

12.9416 mL

25.8833 mL

5 mM

0.5177 mL

2.5883 mL

5.1767 mL

10 mM

0.2588 mL

1.2942 mL

2.5883 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Choi SM, et al. Effects of DA-6034, a flavonoid derivative, on mucin-like glycoprotein and ocular surface integrity in a rabbit model. Arzneimittelforschung. 2009;59(10):498-503. ;Kwak DS, Lee OY, Lee KN, et al. The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model. Gut Liver. 2016;10(3):406-411. [Content Brief]

[2]. Kwak DS, Lee OY, Lee KN, et al. The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model. Gut Liver. 2016;10(3):406-411. ;Kim YW, Lee WH, Choi SM, et al. DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. J Gastroenterol Hepatol. 2012;27(2):397-405. [Content Brief]

[3]. Nam SY, et al. DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp Biol Med (Maywood). 2008;233(2):180-191. [Content Brief]

[4]. Yang YM, et al. DA-6034 Induces [Ca(2+)]i Increase in Epithelial Cells. Korean J Physiol Pharmacol. 2014 Apr;18(2):89-94. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5883 mL	12.9416 mL	25.8833 mL	64.7082 mL
	5 mM	0.5177 mL	2.5883 mL	5.1767 mL	12.9416 mL
	10 mM	0.2588 mL	1.2942 mL	2.5883 mL	6.4708 mL
	15 mM	0.1726 mL	0.8628 mL	1.7256 mL	4.3139 mL
	20 mM	0.1294 mL	0.6471 mL	1.2942 mL	3.2354 mL
	25 mM	0.1035 mL	0.5177 mL	1.0353 mL	2.5883 mL
	30 mM	0.0863 mL	0.4314 mL	0.8628 mL	2.1569 mL
	40 mM	0.0647 mL	0.3235 mL	0.6471 mL	1.6177 mL
	50 mM	0.0518 mL	0.2588 mL	0.5177 mL	1.2942 mL
	60 mM	0.0431 mL	0.2157 mL	0.4314 mL	1.0785 mL
	80 mM	0.0324 mL	0.1618 mL	0.3235 mL	0.8089 mL
	100 mM	0.0259 mL	0.1294 mL	0.2588 mL	0.6471 mL

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Recoflavone

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Cell Proliferation Compound Library

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Mass Spectrometry Human Metabolite Library

RNA Binding Bioactive Compound Library

Lactylation Compound Library

Alle NF-κB Isoform-spezifische Produkte anzeigen

Alle COX Isoform-spezifische Produkte anzeigen

Alle ERK Isoform-spezifische Produkte anzeigen

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Recoflavone Related Classifications

HY-106449 Related Classifications