Art. -Nr.: HY-N2192

Swertianolin

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Swertianolin is a xanthone glycoside. Swertianolin can be isolated from plants of the Gentianaceae family (e.g., Gentiana campestris and Swertia punicea). Swertianolin inhibits p38 phosphorylation and NF-κB activation, and reduces NO and ROS production. Swertianolin exhibits anti-Helicobacter pylori activity with an IC₅₀ of 6.1 μM and a minimum bactericidal concentration of 91.7 μM. Swertianolin modulates immune function in sepsis. Swertianolin is useful in the research of diseases such as Alzheimer's disease, hepatitis B, Helicobacter pylori infection, and sepsis.

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Reinheit: 99.54%
CAS. Nr.: 23445-00-3
Formel: C₂₀H₂₀O₁₁
Molecular Weight:436.37

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Swertianolin Chemical Structure

CAS. Nr.: 23445-00-3

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

AChE

Alle p38 MAPK Isoform-spezifische Produkte anzeigen :

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Alle NO Synthase Isoform-spezifische Produkte anzeigen :

In Vitro

Swertianolin (1.6-25 μg/mL; 8 days) suppresses the expression of HBeAg in HepG₂ cells with an IC₅₀ of 8.0 μg/mL^[2].
Swertianolin (12.5-200 μM; 24-72 h) significantly reduces the secretion of IL-10, NO, ROS, and arginase in MDSCs, inhibits MDSC proliferation, promotes their differentiation into dendritic cells, and improves T-cell activity by blocking the immunosuppressive effect of MDSCs^[3].
Swertianolin exhibits anti-Helicobacter pylori activity with an IC₅₀ of 6.1 μM and a minimum bactericidal concentration of 91.7 μM^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Swertianolin (12.5 μg/kg; i.p.; 7 days) reduces the number of MDSCs in the marrow and spleen, increases CD4₊ T cells in the spleen, decreases immunosuppressive factors, reduces lung damage, and improves the survival rate of septic mice with secondary Legionella pneumophila infection by inhibiting p38 phosphorylation and NF-κB activation^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-week-old C57BL/6 mice (weight 25-30 g) with sepsis induced by cecal ligation and puncture (CLP) ^[5]
Dosage:

12.5 μg/kg
Administration:

intraperitoneal injection; 7 days (from the 5th day after CLP surgery)
Result:

Reduced the proportion of MDSCs in the marrow (58.81% vs 87.89% in normal saline group) and spleen (28.60% vs 48.02% in normal saline group).
Increased CD4₊ T cells in the spleen (28.99% vs 20.44% in normal saline group).
Decreased plasma concentrations of IL-10, NO, ROS, and arginase; reduced lung damage and improved survival rate after Legionella pneumophila challenge by inhibiting p38 phosphorylation and NF-κB activation.

Chemical Information

CAS. Nr. 23445-00-3
Appearance Solid
Molecular Weight 436.37
Formel C₂₀H₂₀O₁₁
Color White to yellow
SMILES

O=C1C2=C(OC3=C1C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC=C3O)C=C(OC)C=C2O
Structure Classification
- Phenols
- Polyphenols
- Phenols
- Xanthones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (57.29 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2916 mL

11.4582 mL

22.9163 mL

5 mM

0.4583 mL

2.2916 mL

4.5833 mL

10 mM

0.2292 mL

1.1458 mL

2.2916 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Urbain A, et al. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004 Oct;70(10):1011-4. [Content Brief]

[2]. Xiu-Qiao Zhang, et al. Anti-HBV Activities of Xanthones From Swertia Punicea Hemsl. N A J Med Sci. 2014;7(2):72-74.

[3]. Ren Z, et al. Swertianolin ameliorates immune dysfunction in sepsis via blocking the immunosuppressive function of myeloid- derived suppressor cells. Eur J Histochem. 2021 Sep 1;65(3):3292. [Content Brief]

[4]. Suzuki R, et al. Anti-Helicobacter pylori activity of swertianolin, isolated from swertia herb. J Nat Med. 2023 Sep;77(4):1005-1008. [Content Brief]

[5]. Tang H, et al. Swertianolin regulates immunosuppression of myeloid suppressor cells in septic mice by inhibiting NF-κB and P38 signaling. Transpl Immunol. 2025 May;90:102217. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2916 mL	11.4582 mL	22.9163 mL	57.2908 mL
	5 mM	0.4583 mL	2.2916 mL	4.5833 mL	11.4582 mL
	10 mM	0.2292 mL	1.1458 mL	2.2916 mL	5.7291 mL
	15 mM	0.1528 mL	0.7639 mL	1.5278 mL	3.8194 mL
	20 mM	0.1146 mL	0.5729 mL	1.1458 mL	2.8645 mL
	25 mM	0.0917 mL	0.4583 mL	0.9167 mL	2.2916 mL
	30 mM	0.0764 mL	0.3819 mL	0.7639 mL	1.9097 mL
	40 mM	0.0573 mL	0.2865 mL	0.5729 mL	1.4323 mL
	50 mM	0.0458 mL	0.2292 mL	0.4583 mL	1.1458 mL

Keywords

Swertianolin

1 Cited Publications

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Swertianolin

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Publications Citing Use of MedChemExpress (MCE) Swertianolin

Alle p38 MAPK Isoform-spezifische Produkte anzeigen

Alle NF-κB Isoform-spezifische Produkte anzeigen

Alle NO Synthase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Swertianolin Related Classifications