Validamycin A
Based on 1 publication(s) in Google Scholar
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.
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- Reinheit : 60.0%
- CAS. Nr.: 37248-47-8
- Formel: C20H35NO13
- Molecular Weight:497.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-N1132
D-(+)-TrehaloseDisaccharide -
HY-N1430
OxyresveratrolAutophagy Inducer -
HY-W017212
Methyl cinnamateTyrosinase Inhibitor -
HY-N4005
IsoastilbinBacterial Inhibitor -
HY-108935
Lavendustin BHIV-1 Integrase Inhibitor -
HY-W017212R
Methyl cinnamate (Standard)Tyrosinase Inhibitor -
HY-N1430R
Oxyresveratrol (Standard)Autophagy Inducer
Publications Citing Use of MedChemExpress (MCE) Validamycin A
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Biologische Aktivität
Beschreibung
IC50 & Target
Antibiotic[1], IC50: 72 μM (trehalase)[2], Ki: 5.893 mM (tyrosinase)[3]
In Vitro
Validamycin A (0.5-1 μg/mL; 18 hours) inhibits the growth of A. flavus and delayed conidial germination[1].
Validamycin A shows no cytotoxicity to human bronchial epithelial cells[1].
Validamycin A directly binds to several residues in the active site of tyrosinase, including HIS85, HIS244, GLU256, HIS259 and ASN260[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Aspergillus flavus ATCC204304
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Concentration:0.5 μg/mL, 1 μg/mL
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Incubation Time:18 hours
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Result:Inhibited the growth of Aspergillus flavus.
Chemical Information
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CAS. Nr. 37248-47-8
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Appearance Solid
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Molecular Weight 497.49
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Formel C20H35NO13
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Color White to off-white
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SMILES
O[C@H]1[C@@H](N[C@H]2C=C(CO)[C@@H](O)[C@H](O)[C@H]2O)C[C@H](CO)[C@@H](O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)[C@@H]1O
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Structure Classification
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Initial Source
Streptomyces hygroscopicus
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Pest Manag Sci
Trehalose metabolism mediates trade-offs between reproduction and survival in beet webworm, Loxostege sticticalis, under heat stress. [Abstract]2025 Feb;81(2):903-911. PMID: 39435696
Lösungsmittel & Löslichkeit
In Vitro:
H2O : 125 mg/mL (251.26 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (201.01 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Napasawan Plabutong, et al. The Inhibitory Effect of Validamycin A on Aspergillus flavus. Int J Microbiol. 2020; 2020: 3972415. [Content Brief]
[2]. N Asano, et al. Effect of validamycins on glycohydrolases of Rhizoctonia solani. J Antibiot (Tokyo). 1987 Apr;40(4):526-32. [Content Brief]
[3]. Zhi-Jiang Wang, et al. The effect of validamycin A on tyrosinase: inhibition kinetics and computational simulation. Int J Biol Macromol. 2013 Apr;55:15-23. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0101 mL | 10.0505 mL | 20.1009 mL | 50.2523 mL |
| 5 mM | 0.4020 mL | 2.0101 mL | 4.0202 mL | 10.0505 mL | |
| 10 mM | 0.2010 mL | 1.0050 mL | 2.0101 mL | 5.0252 mL | |
| 15 mM | 0.1340 mL | 0.6700 mL | 1.3401 mL | 3.3502 mL | |
| 20 mM | 0.1005 mL | 0.5025 mL | 1.0050 mL | 2.5126 mL | |
| 25 mM | 0.0804 mL | 0.4020 mL | 0.8040 mL | 2.0101 mL | |
| 30 mM | 0.0670 mL | 0.3350 mL | 0.6700 mL | 1.6751 mL | |
| 40 mM | 0.0503 mL | 0.2513 mL | 0.5025 mL | 1.2563 mL | |
| 50 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0050 mL | |
| 60 mM | 0.0335 mL | 0.1675 mL | 0.3350 mL | 0.8375 mL | |
| 80 mM | 0.0251 mL | 0.1256 mL | 0.2513 mL | 0.6282 mL | |
| 100 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5025 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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