Cat. No.: HY-N5064

Bacoside A3

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Bacoside A3 is a triterpenoid saponin isolated from Bacopa monnieri. Bacoside A3 has neuroprotective activity, downregulating β-amyloid-induced inflammatory responses and inhibiting neuronal apoptosis. Bacoside A3 can be used in the study of Alzheimer's disease.

For research use only. We do not sell to patients.

Purity: 99.85%
CAS No.: 157408-08-7
Formula: C₄₇H₇₆O₁₈
Molecular Weight:929.10

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Bacoside A3 Chemical Structure

CAS No.: 157408-08-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NO Synthase Isoforms :

All COX Isoforms :

In Vitro

Bacoside A3 (0.5-5 μM; 24 h) prevents β-amyloid (10 μM)-mediated growth inhibition of U87MG cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

U87MG cells
Concentration:

0.5, 1, 1.5, 2.5 and 5 μM
Incubation Time:

24 h
Result:

Inhibited the formation of iNOS mediated by β-amyloid in U87MG cells in a dose-dependent manner and completely alleviated the effect of β-amyloid on iNOS synthesis at a dose of 5 μM.

RT-PCR^[2]

Cell Line:

U87MG cells
Concentration:

0.5, 1, 1.5, 2.5 and 5 μM
Incubation Time:

24 h
Result:

Inhibited overexpression of COX-2 mRNA, and the inhibition level of COX-2 level in U87MG cells at a dose of 5 μM is close to that of the control group.

Chemical Information

CAS No. 157408-08-7
Appearance Solid
Molecular Weight 929.10
Formula C₄₇H₇₆O₁₈
Color White to off-white
SMILES

C[C@]12[C@@]34[C@@](CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O[C@@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H](CO)[C@H](O)[C@H]8O)CC5)C)([H])CC2)C)([H])[C@]9([H])[C@@](OC4)(O[C@@H](/C=C(C)/C)C[C@@]9(O)C)C3
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Int J Mol Sci

From Tradition to Translation: A Critical Appraisal of Bacopa monnieri for Neuroprotection from Preclinical and Clinical Perspectives and Challenges in Utilization. [Abstract]

2026 Jun 17;27(12):5488. PMID: 42353204

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (107.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0763 mL

5.3816 mL

10.7631 mL

5 mM

0.2153 mL

1.0763 mL

2.1526 mL

10 mM

0.1076 mL

0.5382 mL

1.0763 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vini C Sekhar, et al. Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I. Curr Neuropharmacol. 2019;17(5):438-446. [Content Brief]

[2]. Bai Q, et al. Isolation and neuronal apoptosis inhibitory property of bacoside‐A3 via downregulation of β‐amyloid induced inflammatory response[J]. Biotechnology and applied biochemistry, 2022, 69(2): 726-734. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0763 mL	5.3816 mL	10.7631 mL	26.9078 mL
	5 mM	0.2153 mL	1.0763 mL	2.1526 mL	5.3816 mL
	10 mM	0.1076 mL	0.5382 mL	1.0763 mL	2.6908 mL
	15 mM	0.0718 mL	0.3588 mL	0.7175 mL	1.7939 mL
	20 mM	0.0538 mL	0.2691 mL	0.5382 mL	1.3454 mL
	25 mM	0.0431 mL	0.2153 mL	0.4305 mL	1.0763 mL
	30 mM	0.0359 mL	0.1794 mL	0.3588 mL	0.8969 mL
	40 mM	0.0269 mL	0.1345 mL	0.2691 mL	0.6727 mL
	50 mM	0.0215 mL	0.1076 mL	0.2153 mL	0.5382 mL
	60 mM	0.0179 mL	0.0897 mL	0.1794 mL	0.4485 mL
	80 mM	0.0135 mL	0.0673 mL	0.1345 mL	0.3363 mL
	100 mM	0.0108 mL	0.0538 mL	0.1076 mL	0.2691 mL

Keywords

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Bacoside A3

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Aging Compound Library

Glycoside Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Anti-Alzheimer's Disease Compound Library

Neuroprotective Compound Library

Neurodegenerative Disease-related Compound Library

Angiogenesis-Related Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Mitochondrial Protection Compound Library

Metabolic Enzyme Compound Library

Membrane Protein-targeted Compound Library

Cell Death Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Anti-Rheumatic Arthritis Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Bacoside A3

All NO Synthase Isoforms

All COX Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Bacoside A3 Related Classifications

HY-N5064 Related Classifications