country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-180941

Copy Link Print Information

Bfl-1-IN-7

Bfl-1-IN-7 is an orally active and selective Bfl-1 inhibitor with an IC₅₀ value of 0.015 μM. Bfl-1-IN-7 activates caspase 3/7, and when combined with the Mcl-1 inhibitor AZD5991 (HY-101533), it reduces the viability of lymphoma cells. Bfl-1-IN-7 can be used in lymphoma-related studies.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₄H₂₆F₃N₃O₃
Molecular Weight:461.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Bfl-1-IN-7 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Bfl-1

0.015 μM (IC₅₀)

Caspase-3

Caspase-7

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SU-DHL-1	EC50	0.31 μM	Induction of caspase activation (a marker of apoptosis) in SU-DHL-1 lymphoma cells when combined with Mcl-1 inhibitor AZD5991, measured after 6-hour incubation. Induction of caspase activation (a marker of apoptosis) in SU-DHL-1 lymphoma cells when combined with Mcl-1 inhibitor AZD5991, measured after 6-hour incubation.	41432228
SU-DHL-1	EC50	0.21 μM	Reduction of SU-DHL-1 lymphoma cell viability measured after 24-hour incubation. Reduction of SU-DHL-1 lymphoma cell viability measured after 24-hour incubation.	41432228
KARPAS-422	EC50	>10 μM	Lack of cell viability reduction in Bfl-1-null Karpas-422 cells, with no effect observed at concentrations up to 10 μM after 24-hour incubation. Lack of cell viability reduction in Bfl-1-null Karpas-422 cells, with no effect observed at concentrations up to 10 μM after 24-hour incubation.	41432228

In Vitro

Bfl-1-IN-7 (compound 25) potently and selectively inhibits purified Bfl-1 protein with an IC₅₀ of 0.015 μM. When combined with the Mcl-1 inhibitor AZD5991 (HY-101533), it induces caspase activation in SU-DHL-1 lymphoma cells with an EC₅₀ of 0.31 μM^[1].
Bfl-1-IN-7 (0.2-20 μM; 4 h) covalently labels the C55 residue of Bfl-1 in LY10 lymphoma cells in a dose-dependent and selective manner, with extremely low off-target activity against BTK C481^[1].
Bfl-1-IN-7 potently inhibits Bfl-1 in biochemical FRET assays, with a mean pIC₅₀ of 7.809; in combination with AZD5991, it induces caspase 3/7 activation in SU-DHL-1 cells, with a mean pEC₅₀ of 6.503^[1].
Bfl-1-IN-7 covalently binds to purified Bfl-1 in a concentration- and time-dependent manner, and its observed rate constant increases with the elevation of compound concentration^[1].
Bfl-1-IN-7 reduces the viability of SU-DHL-1 lymphoma cells, with an EC₅₀ of 0.21 μM at 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	V_ss	T_1/2	F
Mice^[1]	0.5 mg/kg	i.v.	111 mL/min/kg	13.6 L/kg	2.4 h	/
Mice^[1]	1 mg/kg	p.o.	/	/	/	53 %

Chemical Information

Molecular Weight 461.48
Formel C₂₄H₂₆F₃N₃O₃
SMILES

C=CC(N([C@@H](C)C1=CC=C(NC([C@@H]2CCC[C@H]2N)=O)C=C1)C3=CC=C(OC(F)(F)F)C=C3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Blackwell JH, et al. Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool. Journal of medicinal chemistry. 2026 Jan 22;69(2):1218-1246. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Bfl-1-IN-7

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen