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Cat. No.: HY-101619

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Abaperidone

Name: Abaperidone
Brand: MedChemExpress
SKU: HY-101619
Price: 646.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Abaperidone is a potent antagonist of 5-HT_2A receptor and dopamine D₂ receptor with IC₅₀s of 6.2 and 17 nM.

For research use only. We do not sell to patients.

CAS No.: 183849-43-6
Formula: C₂₅H₂₅FN₂O₅
Molecular Weight:452.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Abaperidone Chemical Structure

CAS No.: 183849-43-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Abaperidone is a potent antagonist of 5-HT_2A receptor and dopamine D₂ receptor with IC₅₀s of 6.2 and 17 nM.

IC₅₀ & Target

5-HT_2A Receptor

D₂ Receptor

17 nM (IC₅₀)

5-HT_2A Receptor

6.2 nM (IC₅₀)

All Dopamine Receptor Isoforms :

All 5-HT Receptor Isoforms :

In Vitro

Abaperidone possesses good affinity for dopamine D₂ receptors, together with a greater affinity for 5-HT₂ receptors with IC₅₀ of 17 and 6.2 nM, reaspectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

The time course of the inhibition of climbing behavior for a period of several hours after oral administration of either 0.5 mg/kg of Abaperidone or risperidone is tested in mice. Also is included a comparative test of catalepsy induced by Abaperidone and risperidone along several hours following oral administration at several doses in rats. A somewhat lesser induction of catalepsy is observed for Abaperidone. A study of serum prolactin levels after oral administration of Abaperidone, haloperidol, and risperidone at 5 mg/kg for either 1 or 3 days in rats. Increases in prolactin levels after oral administration of Abaperidone are smaller than those for reference drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 183849-43-6
Molecular Weight 452.47
Formula C₂₅H₂₅FN₂O₅
SMILES

O=C1C(CO)=COC2=CC(OCCCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=CC=C12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bolós J, et al. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Abaperidone

All Dopamine Receptor Isoforms

All 5-HT Receptor Isoforms