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Gallic acid

(Synonyms: 3,4,5-Trihydroxybenzoic acid)
18 Cited Publications
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Based on 18 publication(s) in Google Scholar

Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.

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  • Purity: 99.99%
  • CAS No.: 149-91-7
  • Formula: C7H6O5
  • Molecular Weight:170.12
  • Storage:

    Store at room temperature 3 years.

    In solvent   -80°C, 2 years , -20°C, 1 year
  • Gallic acid Chemical Structure
    Gallic acid Chemical Structure
  • Experimental Validation Results for Gallic acid
  • Experimental Validation Results for Gallic acid
  • Experimental Validation Results for Gallic acid
  • Experimental Validation Results for Gallic acid
  • Experimental Validation Results for Gallic acid
  • Experimental Validation Results for Gallic acid
  • Experimental Validation Results for Gallic acid
CAS No.: 149-91-7
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  • Gallic acid Chemical Structure
    Gallic acid Chemical Structure
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    Gallic acid purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jan 8;23(1):30. [Abstract]

    Customer Validation
     Hematoxylin and eosin (HE) and Sirius red staining revealed that after intervention with the ferroptosis inhibitor Fer-1 or Gallic acid (GA) (200 mg/kg/d, i.g.), the muscle fibers were more orderly arranged, and some muscle cells exhibited mild edema and a small amount of inflammatory cell infiltration.

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    Gallic acid purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jan 8;23(1):30. [Abstract]

    Customer Validation
     Detection of IL-6, TNF-α, CK, LDH, Fe2+ and MDA levels significantly reduced treated with Gallic acid (GA) (200 mg/kg/d, i.g.) in skeletal muscle tissue by ELISA.

  • 1/16

    Gallic acid purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jan 8;23(1):30. [Abstract]

    Customer Validation
     After Gallic acid (GA) (200 mg/kg/d, i.g.) intervention, both Piezo1 and COX2 were significantly decreased, and the expression of GPX4 and FTH1 was increased by Western blot.

  • 1/16

    Gallic acid purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jan 8;23(1):30. [Abstract]

    Customer Validation
     Detection of Piezo1, GPX4, FTH1 and COX2 mRNA levels treated with Gallic acid (GA) (200 mg/kg/d, i.g.) in skeletal muscle tissue by RT-qPCR.

  • 1/16

    Gallic acid purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Jan 8;23(1):30. [Abstract]

    Customer Validation
     Immunohistochemical detection of Piezo1 and GPX4 expression treated with Gallic acid (GA) (200 mg/kg/d, i.g.) in skeletal muscle tissue of different groups of mice.

  • 1/16

    Gallic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751. [Abstract]

    Customer Validation
     A549 cells were pre-treated with active compounds (Gallic acid, Chebulagic acid, and Chebulinic acid) (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The IL-6 (A), IL-1β (B), and IL-18 secretions (C) in the culture supernatant were examined by ELISA.

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    Gallic acid purchased from MedChemExpress. Usage Cited in: Pharmaceutics. 2024 Jun 2;16(6):751. [Abstract]

    Customer Validation
     Inhibitory effects of active compounds (Gallic acid, Chebulagic acid and Chebulinic acid) on the IL-6 (A), IL-1β (B), IL-18 (C), and NLRP3 gene expressions (D) in CoV2-SP-induced A549 cells. A549 cells were pre-treated with active compounds (gallic acid, chebulagic acid and chebulinic acid) (0–20 µg/mL) for 24 h. Then, the cells were exposed to CoV2-SP (100 ng/mL) for 3 h. The mRNA expressions were determined using RT-qPCR.

  • Gallic acid