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Cat. No.: HY-147716

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CDK8-IN-6

CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an K_d of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC₅₀s of 11.2, 7.5, 8.6, 20.5, 12.5-25 µM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer.

For research use only. We do not sell to patients.

CAS No.: 2415156-27-1
Formula: C₂₆H₃₇ClN₂
Molecular Weight:413.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CDK8-IN-6 Chemical Structure

CAS No.: 2415156-27-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

CDK8

13 nM (Kd)

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
H9c2	EC₅₀	12.5 μM Compound: 9	Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
MOLM-13	EC₅₀	11.2 μM Compound: 9	Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
MV4-11	EC₅₀	8.6 μM Compound: 9	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
NRK	EC₅₀	20.5 μM Compound: 9	Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
OCI-AML-3	EC₅₀	7.5 μM Compound: 9	Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]

Chemical Information

CAS No. 2415156-27-1
Molecular Weight 413.04
Formula C₂₆H₃₇ClN₂
SMILES

C[C@@]12C(C3=CC(Cl)=CN=C3)=CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](N(C)C)CC[C@]5(C)[C@@]4([H])CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CDK8-IN-6

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CDK8-IN-6 Related Classifications

HY-147716 Related Classifications