LPAR3 - lysophosphatidic acid receptor 3 Gene

Also Known as EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23566

About LPAR3

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,811,602-84,893,206 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 18 paralogues. Biased expression in prostate (RPKM 8.7), testis (RPKM 8.1) and 12 other tissues.

Summary

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

LPAR3 Products (1)

mRNA Protein Name
NM_012152.3 NP_036284.1 lysophosphatidic acid receptor 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (48 - 293)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 3

  • LPA receptor 3

  • LPA receptor EDG7

  • LPA-3

  • calcium-mobilizing lysophosphatidic acid receptor LP-A3

  • endothelial cell differentiation gene 7

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7

  • lysophosphatidic acid receptor Edg-7

LPAR3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LPAR3 Q9UBY5 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM41A Homo sapiens Q96HV5
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 TMEM41A Homo sapiens Q96HV5
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 SGMS2 Homo sapiens Q8NHU3
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 SGMS2 Homo sapiens Q8NHU3
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TFEC Homo sapiens O14948-3
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CLEC12B Homo sapiens Q2HXU8-2
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CLEC12B Homo sapiens Q2HXU8-2
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 MS4A4A Homo sapiens Q96JQ5
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 MS4A4A Homo sapiens Q96JQ5
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 KCNC1 Homo sapiens P48547
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 KCNC1 Homo sapiens P48547
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 C16orf54 Homo sapiens Q6UWD8
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 C16orf54 Homo sapiens Q6UWD8
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CLDN9 Homo sapiens O95484
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CLDN9 Homo sapiens O95484
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 NDUFAF2 Homo sapiens Q8N183
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 NDUFAF2 Homo sapiens Q8N183
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 EDA Homo sapiens Q92838
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 EDA Homo sapiens Q92838
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM70 Homo sapiens Q9BUB7
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM70 Homo sapiens Q9BUB7
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CLDN2 Homo sapiens P57739
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CLDN2 Homo sapiens P57739
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
LPAR3 Q9UBY5 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
LPAR3 Q9UBY5 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM79 Homo sapiens Q9BSE2
Y2H Array
32296183
Intra
LPAR3 Q9UBY5 TMEM79 Homo sapiens Q9BSE2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

LPAR3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811031 EDG7 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Hutchinson-Gilford Progeria Syndrome

  • Progeria

  • HGPS

  • Hutchinson-Gilford Syndrome

  • Hutchinson-Gilford Progeria

  • Hutchinson Gilford Syndrome

  • Hutchinson-Gilford Disease

  • Hutchinson Gilford Progeria Syndrome

  • Progeria Of Childhood

  • Hutchinson-Gilford-Progeria Syndrome
Trachea Carcinoma

  • Pancoast Tumor

  • Carcinoma Of The Trachea

  • Pancoast'S Tumor

  • Malignant Superior Sulcus Tumor

  • Malignant Superior Sulcus Tumour

  • Pancoast Tumour

  • Pancoast'S Syndrome

  • Pancoast'S Tumour

  • Pulmonary Sulcus Tumor

  • Pulmonary Sulcus Tumour

  • Superior Pulmonary Sulcus Syndrome

  • Pancoast Syndrome
Triple-Receptor Negative Breast Cancer
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Cancer Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Tracheal Cancer

  • Tracheal Carcinoma

  • Malignant Neoplasm Of Trachea

  • Tracheal Neoplasms

  • Pancoast Tumor

  • Pulmonary Sulcus Neoplasm

  • Pancoast Syndrome
Trachea Adenoid Cystic Carcinoma

  • Tracheal Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Trachea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15706 H2L 5765834 Antagonist 98.66% Unkown
HY-178845 Decyl phosphate Modulator / Unkown
HY-W725737 BrP-LPA Antagonist / Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LPAR3 VGNC VGNC:63263
Macaca mulatta LPAR3 VGNC VGNC:74287
Canis familiaris LPAR3 VGNC VGNC:42744
Mus musculus LPAR3 MGD MGI:1929469
Bos taurus LPAR3 VGNC VGNC:30957
Rattus norvegicus LPAR3 RGD RGD:620565
Others LPAR3 NCBI