XBP1 - X-box binding protein 1 Gene

Also Known as XBP2; TREB5; XBP-1; TREB-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7494

About XBP1

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:28,794,560-28,800,569 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and is associated with 1 phenotype. Ubiquitous expression in salivary gland (RPKM 196.1), urinary bladder (RPKM 191.7) and 25 other tissues.

Summary

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of Viral Proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the Endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

XBP1 Products (4)

mRNA	Protein	Name
NM_001079539.2	NP_001073007.1	X-box-binding protein 1 isoform XBP1(S)
NM_001393999.1	NP_001380928.1	X-box-binding protein 1 isoform 3
NM_001394000.1	NP_001380929.1	X-box-binding protein 1 isoform 4
NM_005080.4	NP_005071.2	X-box-binding protein 1 isoform XBP1(U)

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1903538	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11779464	GOA
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	25280941	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	2196176	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	25239945	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16461360	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	1903538	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20348923	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	23184933	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25239945	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to fluid shear stress	IDA IDA: Inferred from direct assay	25190803	GOA
involved in cellular response to laminar fluid shear stress	IDA IDA: Inferred from direct assay	25280941	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	11460154	GOA
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	25190803	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	23529610	GOA
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	25239945	GOA
involved in endothelial cell proliferation	IDA IDA: Inferred from direct assay	23529610	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	26315405	GOA
involved in negative regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	26315405	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19135031	GOA
involved in negative regulation of endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	25239945	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16461360	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	26315405	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	23529610	GOA
involved in positive regulation of B cell differentiation	IDA IDA: Inferred from direct assay	11460154	GOA
involved in positive regulation of MHC class II biosynthetic process	IMP IMP: Inferred from mutant phenotype	1903538	GOA
involved in positive regulation of T cell differentiation	IDA IDA: Inferred from direct assay	11460154	GOA
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	25190803	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	25656649	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	23184933	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	25656649	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	25656649	GOA
involved in positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	25656649	GOA
involved in positive regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	25280941	GOA
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	11460154	GOA
NOT involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	26315405	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	26315405	GOA
involved in positive regulation of plasma cell differentiation	IDA IDA: Inferred from direct assay	11460154	GOA
involved in positive regulation of protein acetylation	IDA IDA: Inferred from direct assay	25280941	GOA
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	25190803	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	25190803	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8657566	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	1903538	GOA
NOT involved in positive regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	26315405	GOA
involved in positive regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	26315405	GOA
NOT involved in positive regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	26315405	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	26315405	GOA
involved in positive regulation of vascular wound healing	IDA IDA: Inferred from direct assay	25656649	GOA
involved in protein destabilization	IDA IDA: Inferred from direct assay	16461360	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	25280941	GOA
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	23529610	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	25190803	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11779464	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	23529610	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16461360	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20348923	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23529610	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	25239945	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	16461360	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16461360	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XBP1 Protein Structure

bZIP_2

0
100
200
261 a.a.

Protein Preferred Names	Protein Names
X-box-binding protein 1	tax-responsive element-binding protein 5

XBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XBP1	P17861	UBE2V1	Homo sapiens	Q13404	Validated Y2H	32296183
Intra	XBP1	P17861	ATF6B	Homo sapiens	Q99941	FRET	23661758
Intra	XBP1	P17861	CREBZF	Homo sapiens	Q9NS37	Peptide Array	20102225
Intra	XBP1	P17861	CREBZF	Homo sapiens	Q9NS37	FRET	23661758
Intra	XBP1	P17861	XBP1	Homo sapiens	P17861	Peptide Array	20102225
Intra	XBP1	P17861	XBP1	Homo sapiens	P17861	FRET	23661758
Intra	XBP1	P17861	XBP1	Homo sapiens	P17861	Peptide Array	12805554
Intra	XBP1	P17861	ATF6	Homo sapiens	P18850	FRET	23661758
Intra	XBP1	P17861	ATF6	Homo sapiens	P18850	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

XBP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81679	XBP1 Antibody (YA1424)	WB, IP	Human, Mouse
HY-P81679A	XBP1 Antibody (YA1424)(PBS only)	WB, IP	Human, Mouse
HY-P85412	XBP1 Antibody (YA5104)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue	Human, Mouse, Rat
HY-P86543	XBP1 Antibody (YA6235)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Major Affective Disorder 7	MAFD7 Bipolar Affective Disorder Major Affective Disorder-7, Susceptibility To Major Affective Disorder-7 Manic Depressive Illness Manic-Depressive Psychosis Major Affective Disorder 7, Susceptibility To Bipolar Disorder Major Affective Disorder 2 Major Affective Disorder 1
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus	Wolcott-Rallison Syndrome Med-Iddm Syndrome Iddm-Med Syndrome Wolcott Rallison Syndrome WRS Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Ileocolitis	Iieocolitis
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Wolfram Syndrome 1	WFS1 Didmoad Wfs Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome Wolfram Syndrome
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Retinal Degeneration	Degeneration Of Retina
Cardiomyopathy, Familial Hypertrophic, 16	Hypertrophic Cardiomyopathy 16 CMH16 Cardiomyopathy, Hypertrophic, 16 Cardiomyopathy Familial Hypertrophic 16 Cardiomyopathy, Familial Hypertrophic 16 Cardiomyopathy, Hypertrophic, Familial, Type 16
Cardiomyopathy, Familial Hypertrophic, 18	Hypertrophic Cardiomyopathy 18 CMH18 Cardiomyopathy, Hypertrophic, 18 Cardiomyopathy Familial Hypertrophic 18 Cardiomyopathy, Familial Hypertrophic 18 Cardiomyopathy, Hypertrophic, Familial, Type 18
Cardiomyopathy, Familial Hypertrophic, 17	Hypertrophic Cardiomyopathy 17 CMH17 Cardiomyopathy, Hypertrophic, 17 Cardiomyopathy Familial Hypertrophic 17 Cardiomyopathy, Familial Hypertrophic 17 Cardiomyopathy, Hypertrophic, Familial, Type 17
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Diabetes Mellitus	Diabetes
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-104040	MKC8866	Inhibitor	99.95%	Phase 2

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139214	IXA4	Inhibitor	98.92%	Unkown
HY-100355	C18-Ceramide (d18:1/18:0)		99.95%	Unkown
HY-103248	Toyocamycin		99.27%	Unkown
HY-124293	AA147	Activator	99.81%	Unkown
HY-160229	ssRNA40 sodium		98.34%	Unkown
HY-W018161	Hexadecanedioic acid	Inhibitor	98.0%	Unkown
HY-139212	IXA6	Activator	99.29%	Unkown
HY-W020952	Palladium(Ⅱ) acetylacetonate		98.2%	Unkown
HY-161672	G-5758	Inhibitor	98.91%	Unkown
HY-176040	IXA62	Inhibitor	99.55%	Unkown
HY-U00460	3,6-DMAD hydrochloride	Inhibitor	99.50%	Unkown
HY-124646	KIRA-7	Inhibitor	99.09%	Unkown
HY-18509	IRE1α kinase-IN-2	Inhibitor	99.24%	Unkown
HY-178946	IA107	Inhibitor	98.14%	Unkown
HY-RS15865	XBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-123996	3-Ethoxy-5,6-dibromosalicylaldehyde		/	Unkown
HY-135945	Dihydrocoptisine		/	Unkown
HY-145425	PAIR2		/	Unkown
HY-158386	IRE1a-IN-1	Inhibitor	/	Unkown
HY-158393	IRE1a-IN-2	Inhibitor	/	Unkown
HY-168843	PSP205	Inducer	/	Unkown
HY-173497	IRE1-IN-2	Inhibitor	/	Unkown
HY-181886	AK177		/	Unkown
HY-U00460B	3,6-DMAD dihydrochloride	Inhibitor	/	Unkown
HY-W018161S	Hexadecanedioic acid-d28		99.21%	Unkown
HY-138844	3-AP-Me	Activator	/	Unkown
HY-RS16677	Xbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23112	Xbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	XBP1	MGD	MGI:98970
Bos taurus	XBP1	VGNC	VGNC:53930
Rattus norvegicus	XBP1	RGD	RGD:1303073
Felis catus	XBP1	VGNC	VGNC:67102
Macaca mulatta	XBP1	VGNC	VGNC:78806
Others	XBP1	NCBI