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Cat. No.: HY-FL14956A

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Nemonoxacin malate solution

Name: Nemonoxacin malate solution
Brand: MedChemExpress
SKU: HY-FL14956A
Availability: PreOrder

(Synonyms: TG-873870 malate hemihydrate solution)

Nemonoxacin malate solution is mainly composed of Nemonoxacin malate hemihydrate (HY-14956A). Nemonoxacin (TG-873870) malate is a nonfluorinated quinolone antibiotic. Nemonoxacin malate has broad-spectrum activity against Gram-positive, Gram-negative and atypical pathogens. Nemonoxacin malate can inhibit drug-resistant Streptococcus pneumoniae and Methicillin-resistant Staphylococcus aureus. Nemonoxacin malate can be used for the research of community-acquired pneumonia.

For research use only. We do not sell to patients.

CAS No.: 951313-26-1
Formula: C₂₀H₂₅N₃O₄·C₄H₆O₅·1/2H₂O
Molecular Weight:514.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nemonoxacin malate solution Chemical Structure

CAS No.: 951313-26-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Antibiotic Isoforms :

Chemical Information

CAS No. 951313-26-1
Molecular Weight 514.54
Formula C₂₀H₂₅N₃O₄·C₄H₆O₅·1/2H₂O
SMILES

OC(CC(O)C(O)=O)=O.COC1=C2N(C3CC3)C=C(C(C2=CC=C1N4C[C@H](C[C@@H](C4)N)C)=O)C(O)=O.O.[1/2]
Synonyms

TG-873870 malate hemihydrate solution
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Histomorphology

Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo B, Zhang J, Yu J, Wu X, Shi Y, Tsai CY. A liquid chromatography-tandem mass spectrometry assay for the determination of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, in human plasma and urine and its application to a single-dose pharmacokinetic study in healthy Chinese volunteers. Biomed Chromatogr. 2012 Nov;26(11):1333-40.

[2]. Li Y, Zhu D, Sun S, Chang X, Cao Z, Yang Y, Fu X, Li X, Xu J, Zhu Y, Hui F, Xu X, Chen Z, Peng L, Ma Z, Mo B, Li C, Lv Y, Zhao L, Zhu G, He Y, Liu H, Chen J, Wang Y, Liang Y, Lu Y, Qin Z, Yang H, Zhang M, Wu S, Tong Z, Ye F, Xiao Z, Wang X, Qiu C, Kuang J, Huang H, Wang K, Ying K, Jin F, Lv X, Huang Y, Liu D, Wang W, Zhang Y. A multicentre, randomised, double-blind, double-dummy, parallel-controlled, phase 3 clinical trial assessing the efficacy and safety of intravenous nemonoxacin malate vs. levofloxacin for community-acquired pneumonia in adult patients. Int J Antimicrob Agents. 2024 Aug;64(2):107235.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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