AL-LAD
AL-LAD is a 5-HT2A receptor ligand with rat Ki values of 8.1 nM and 3.4 nM. AL-LAD mediates behavioral responses characteristic of serotonergic psychedelics. AL-LAD induces the head-twitch response in male C57BL/6J mice in an inverted-U-shaped dose-dependent manner. AL-LAD exhibits LSD-like behavioral effects in male C57BL/6J mice.
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- CAS No.: 65527-61-9
- Formule: C22H27N3O
- Masse moléculaire:349.47
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Stockage:
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Activité biologique
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Chemical Information
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Activité biologique
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5-HT2A Receptor 8.1 nM (Ki) |
5-HT2A Receptor 3.4 nM (Ki) |
AL-LAD exhibits high affinity for 5-HT2A receptors in rat frontal cortex homogenates, with Ki values of 8.1 nM (vs. [3H]ketanserin) and 3.4 nM (vs. [125I]-R-DOI)[1].
AL-LAD binds to D1 and D2 dopaminergic receptors in rat tissue homogenates with K0.5 values of 189 nM and 12.3 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 6−8 weeks old)[1]
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Dosage:25 µg/kg; 50 µg/kg; 100 µg/kg; 200 µg/kg; 400 µg/kg
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Administration:i.p.; single dose
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Result:Dose-dependently induced HTR with an inverted-U-shaped response; maximal response occurred at 200 μg/kg.
Chemical Information
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CAS No. 65527-61-9
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Masse moléculaire 349.47
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Formule C22H27N3O
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SMILES
[H][C@@]1(CC2=CNC3=CC=CC4=C23)C4=C[C@H](CN1CC=C)C(N(CC)CC)=O
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Synonyms
6-Allyl-6-nor-LSD
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AL-LAD Related Classifications
HY-W743888 Related Classifications
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