Cat. No.: HY-N5064

Bacoside A3

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Based on 1 publication(s) in Google Scholar

Bacoside A3 is a triterpenoid saponin isolated from Bacopa monnieri. Bacoside A3 has neuroprotective activity, downregulating β-amyloid-induced inflammatory responses and inhibiting neuronal apoptosis. Bacoside A3 can be used in the study of Alzheimer's disease.

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Pureté: 99.85%
CAS No.: 157408-08-7
Formule: C₄₇H₇₆O₁₈
Masse moléculaire:929.10

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Bacoside A3 Chemical Structure

CAS No.: 157408-08-7

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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Voir tous les produits spécifiques à Isoform COX :

In Vitro

Bacoside A3 (0.5-5 μM; 24 h) prevents β-amyloid (10 μM)-mediated growth inhibition of U87MG cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

U87MG cells
Concentration:

0.5, 1, 1.5, 2.5 and 5 μM
Incubation Time:

24 h
Result:

Inhibited the formation of iNOS mediated by β-amyloid in U87MG cells in a dose-dependent manner and completely alleviated the effect of β-amyloid on iNOS synthesis at a dose of 5 μM.

RT-PCR^[2]

Cell Line:

U87MG cells
Concentration:

0.5, 1, 1.5, 2.5 and 5 μM
Incubation Time:

24 h
Result:

Inhibited overexpression of COX-2 mRNA, and the inhibition level of COX-2 level in U87MG cells at a dose of 5 μM is close to that of the control group.

Chemical Information

CAS No. 157408-08-7
Appearance Solid
Masse moléculaire 929.10
Formule C₄₇H₇₆O₁₈
Color White to off-white
SMILES

C[C@]12[C@@]34[C@@](CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O[C@@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H](CO)[C@H](O)[C@H]8O)CC5)C)([H])CC2)C)([H])[C@]9([H])[C@@](OC4)(O[C@@H](/C=C(C)/C)C[C@@]9(O)C)C3
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Int J Mol Sci

From Tradition to Translation: A Critical Appraisal of Bacopa monnieri for Neuroprotection from Preclinical and Clinical Perspectives and Challenges in Utilization. [Abstract]

2026 Jun 17;27(12):5488. PMID: 42353204

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (107.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0763 mL

5.3816 mL

10.7631 mL

5 mM

0.2153 mL

1.0763 mL

2.1526 mL

10 mM

0.1076 mL

0.5382 mL

1.0763 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Vini C Sekhar, et al. Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I. Curr Neuropharmacol. 2019;17(5):438-446. [Content Brief]

[2]. Bai Q, et al. Isolation and neuronal apoptosis inhibitory property of bacoside‐A3 via downregulation of β‐amyloid induced inflammatory response[J]. Biotechnology and applied biochemistry, 2022, 69(2): 726-734. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0763 mL	5.3816 mL	10.7631 mL	26.9078 mL
	5 mM	0.2153 mL	1.0763 mL	2.1526 mL	5.3816 mL
	10 mM	0.1076 mL	0.5382 mL	1.0763 mL	2.6908 mL
	15 mM	0.0718 mL	0.3588 mL	0.7175 mL	1.7939 mL
	20 mM	0.0538 mL	0.2691 mL	0.5382 mL	1.3454 mL
	25 mM	0.0431 mL	0.2153 mL	0.4305 mL	1.0763 mL
	30 mM	0.0359 mL	0.1794 mL	0.3588 mL	0.8969 mL
	40 mM	0.0269 mL	0.1345 mL	0.2691 mL	0.6727 mL
	50 mM	0.0215 mL	0.1076 mL	0.2153 mL	0.5382 mL
	60 mM	0.0179 mL	0.0897 mL	0.1794 mL	0.4485 mL
	80 mM	0.0135 mL	0.0673 mL	0.1345 mL	0.3363 mL
	100 mM	0.0108 mL	0.0538 mL	0.1076 mL	0.2691 mL

Keywords

Bacoside A3

1 Cited Publications

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Bacoside A3

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Publications Citing Use of MedChemExpress (MCE) Bacoside A3

Voir tous les produits spécifiques à Isoform NO Synthase

Voir tous les produits spécifiques à Isoform COX

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Bacoside A3 Related Classifications

HY-N5064 Related Classifications