BW-723C86
Based on 1 publication(s) in Google Scholar
BW-723C86 is an orally active and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats. BW-723C86 dilates pulmonary arteries and inhibits liquid meal-induced gastric accommodation.
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- Pureté : 98.16%
- CAS No.: 160521-72-2
- Formule: C16H19ClN2OS
- Masse moléculaire:322.85
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BW-723C86
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Activité biologique
Description
IC50 & Target
[1]|
5-HT2B Receptor |
In Vitro
BW-723C86 (1-100 nM) induces concentration-dependent relaxation of PGF2α-precontracted pig pulmonary artery with intact endothelium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
BW-723C86 (10-30 mg/kg, i.p. 30 min pre-test) shows anxiolytic effects in rats via 5-HT2B receptor[3].
BW-723C86 (3-10 mg/kg, s.c. 30 min pretest) exerts an appreciable anxiolytic-like profile in rats, with increasing total social interaction[4].
BW-723C86 (5 mg/kg, p.o., 20 or 30 min before the liquid meal) inhibits liquid meal-induced gastric accommodation in normal Hartley guinea pigs[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley (CD) rats (220–250 g) for vogel conflict test[3]
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Dosage:0.3, 1, 3, 10, 30 mg/kg
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Administration:Intraperitoneal injection (i.p.), 30 min pre-test
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Result:Increased the number of punishments accepted in the rat Vogel conflict test over 3 min.
Had no significant effect on either the amount of time spent drinking or the latency to drink.
Did not affect apparent shock sensitivity.
Chemical Information
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CAS No. 160521-72-2
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Appearance Solid
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Masse moléculaire 322.85
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Formule C16H19ClN2OS
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Color White to light brown
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SMILES
NC(C)CC1=CNC2=C1C=C(OCC3=CC=CS3)C=C2.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1-NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity. [Abstract]2025 Aug;12(29):e15276. PMID: 40387572
BW-723C86 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug;12(29):e15276. [Abstract]
BW-723C86 (0-100 μM; 72 h) effectively inhibits the cell viability of K7M2 and LM8 cells.
BW-723C86 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug;12(29):e15276. [Abstract]
BW-723C86 (0, 20, 40 μM; 48 h) promoted the expression of HTR2B protein in K7M2 and LM8 cells.
BW-723C86 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug;12(29):e15276. [Abstract]
BW-723C86 (0, 20, 40 μM; 6 days) inhibited cell proliferation in K7M2 and LM8 cells.
BW-723C86 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug;12(29):e15276. [Abstract]
BW-723C86 (0, 20, 40 μM; 0, 6 h) effectively reduced cell migration in K7M2 and LM8 cells.
BW-723C86 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug;12(29):e15276. [Abstract]
BW-723C86 (0, 20, 40 μM; 24 h) induced cell cycle arrest at the G1 phase in K7M2 and LM8 cells.
BW-723C86 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug;12(29):e15276. [Abstract]
BW-723C86 (10, 20 mg/kg; i.p.; every 2 days for a total of 20 days) significantly reduced tumor growth in murine xenograft models established in C3H mice.
BW-723C86 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug;12(29):e15276. [Abstract]
BW-723C86 (10, 20 mg/kg; i.p.; every 2 days for a total of 20 days) increased HTR2B expression and reduced Ki67 levels in osteosarcoma tumor tissue.
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (309.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (15.49 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (15.49 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Glusa E, et al. Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors. Br J Pharmacol. 2000 Jun;130(3):692-8. [Content Brief]
[2]. Kennett GA, et, al. BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology. 1997 Feb;36(2):233-9. [Content Brief]
[3]. Kennett GA, et, al. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. 1998 Dec;37(12):1603-10. [Content Brief]
[4]. Kennett GA, et al. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br J Pharmacol. 1996 Apr;117(7):1443-8. [Content Brief]
[5]. Miwa H, et al. Impairment of gastric accommodation induced by water-avoidance stress is mediated by 5-HT2B receptors. Neurogastroenterol Motil. 2016 May;28(5):765-78. [Content Brief]
[6]. Matsumoto T, et, al. Effect of Equol on Vasocontractions in Rat Carotid Arteries Treated with High Insulin. Biol Pharm Bull. 2019;42(6):1048-1053. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0974 mL | 15.4871 mL | 30.9741 mL | 77.4353 mL |
| 5 mM | 0.6195 mL | 3.0974 mL | 6.1948 mL | 15.4871 mL | |
| 10 mM | 0.3097 mL | 1.5487 mL | 3.0974 mL | 7.7435 mL | |
| 15 mM | 0.2065 mL | 1.0325 mL | 2.0649 mL | 5.1624 mL | |
| 20 mM | 0.1549 mL | 0.7744 mL | 1.5487 mL | 3.8718 mL | |
| 25 mM | 0.1239 mL | 0.6195 mL | 1.2390 mL | 3.0974 mL | |
| 30 mM | 0.1032 mL | 0.5162 mL | 1.0325 mL | 2.5812 mL | |
| 40 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9359 mL | |
| 50 mM | 0.0619 mL | 0.3097 mL | 0.6195 mL | 1.5487 mL | |
| 60 mM | 0.0516 mL | 0.2581 mL | 0.5162 mL | 1.2906 mL | |
| 80 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9679 mL | |
| 100 mM | 0.0310 mL | 0.1549 mL | 0.3097 mL | 0.7744 mL |
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