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Cat. No.: HY-147716

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CDK8-IN-6

CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an K_d of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC₅₀s of 11.2, 7.5, 8.6, 20.5, 12.5-25 µM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer.

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CAS No.: 2415156-27-1
Formule: C₂₆H₃₇ClN₂
Masse moléculaire:413.04

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CDK8-IN-6 Chemical Structure

CAS No.: 2415156-27-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Description
- IC₅₀ & Target
- Cellular Effect
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Description

IC₅₀ & Target^[1]

CDK8

13 nM (Kd)

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Cellular Effect

Cell Line	Type	Value	Description	References
H9c2	EC₅₀	12.5 μM Compound: 9	Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
MOLM-13	EC₅₀	11.2 μM Compound: 9	Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
MV4-11	EC₅₀	8.6 μM Compound: 9	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
NRK	EC₅₀	20.5 μM Compound: 9	Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against rat NRK cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]
OCI-AML-3	EC₅₀	7.5 μM Compound: 9	Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay Cytotoxicity against human OCI-AML3 cells assessed as reduction in cell viability after 48 hrs by Hoechst 33342 staining-based microscopy and WST-1 assay	[PMID: 32245563]

Chemical Information

CAS No. 2415156-27-1
Masse moléculaire 413.04
Formule C₂₆H₃₇ClN₂
SMILES

C[C@@]12C(C3=CC(Cl)=CN=C3)=CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])C[C@H](N(C)C)CC[C@]5(C)[C@@]4([H])CC2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents - Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CDK8-IN-6

Voir tous les produits spécifiques à Isoform CDK

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CDK8-IN-6 Related Classifications

HY-147716 Related Classifications