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Cat. No.: HY-116664

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DPQZ

DPQZ is an anti-tubulin agent that inhibits cell separation and induces cell cycle arrest at the G2/M phase. In addition, DPQZ induces caspase-dependent apoptosis of HSC-3 cells by inhibiting Ras/Raf and activating MAP kinase. DPQZ can be used in the study of oral cancer.

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CAS No.: 1431362-93-4
Formule: C₂₀H₁₇N₃O
Masse moléculaire:315.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DPQZ Chemical Structure

CAS No.: 1431362-93-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Ras :

Voir tous les produits spécifiques à Isoform Raf :

Voir tous les produits spécifiques à Isoform Caspase :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-15	IC₅₀	0.46 μM Compound: 14	Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay	[PMID: 26334499]
HeLa	IC₅₀	0.05 μM Compound: 14	Cytotoxicity against human HeLa cells measured after 2 days by MTT assay Cytotoxicity against human HeLa cells measured after 2 days by MTT assay	[PMID: 26334499]
T47D	IC₅₀	>50 μM Compound: 14	Cytotoxicity against human T47D cells measured after 2 days by MTT assay Cytotoxicity against human T47D cells measured after 2 days by MTT assay	[PMID: 26334499]

Chemical Information

CAS No. 1431362-93-4
Masse moléculaire 315.37
Formule C₂₀H₁₇N₃O
SMILES

O=C1N=C(C2=C3C=CC=CC3=CC=C2)NC4=CC=C(N(C)C)C=C14
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hour M J, et al. A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation[J]. Archives of toxicology, 2013, 87: 835-846. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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DPQZ

Voir tous les produits spécifiques à Isoform Ras

Voir tous les produits spécifiques à Isoform Raf

Voir tous les produits spécifiques à Isoform Caspase