DXd-d5
Based on 1 Customer Validation
DXd-d5 is a deuterium labeled DXd. DXd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) .
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- Pureté : 99.57%
- Formule: C26H19D5FN3O6
- Masse moléculaire:498.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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Topoisomerase I 0.31 μM (IC50) |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 1599440-33-1
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Appearance Solid
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Masse moléculaire 498.51
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Formule C26H19D5FN3O6
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Color White to off-white
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SMILES
O=C1[C@](O)(C(C([2H])([2H])[2H])([2H])[2H])C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(CO)=O)C(C)=C(F)C=C6N=C4C3=C2)=O
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Synonyms
Exatecan-d5 derivative for ADC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro:
DMSO : ≥ 40 mg/mL (80.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (282 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108. [Content Brief]
[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0060 mL | 10.0299 mL | 20.0598 mL | 50.1494 mL |
| 5 mM | 0.4012 mL | 2.0060 mL | 4.0120 mL | 10.0299 mL | |
| 10 mM | 0.2006 mL | 1.0030 mL | 2.0060 mL | 5.0149 mL | |
| 15 mM | 0.1337 mL | 0.6687 mL | 1.3373 mL | 3.3433 mL | |
| 20 mM | 0.1003 mL | 0.5015 mL | 1.0030 mL | 2.5075 mL | |
| 25 mM | 0.0802 mL | 0.4012 mL | 0.8024 mL | 2.0060 mL | |
| 30 mM | 0.0669 mL | 0.3343 mL | 0.6687 mL | 1.6716 mL | |
| 40 mM | 0.0501 mL | 0.2507 mL | 0.5015 mL | 1.2537 mL | |
| 50 mM | 0.0401 mL | 0.2006 mL | 0.4012 mL | 1.0030 mL | |
| 60 mM | 0.0334 mL | 0.1672 mL | 0.3343 mL | 0.8358 mL | |
| 80 mM | 0.0251 mL | 0.1254 mL | 0.2507 mL | 0.6269 mL |
DXd-d5 Related Classifications
HY-13631DS Related Classifications
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