DYRK2-IN-2
DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC50 value being 40.3 nM. The inhibitory activity of DYRK2-IN-2 on DYRK1A (IC50 = 1842 nM), DYRK1B (IC50 = 1335 nM), DYRK4 (IC50 = 1931 nM), DYRK3 (IC50 = 112 nM), and CLKs (IC50 = 540-6496 NM) is relatively low. DYRK2-IN-2 inhibits the phosphorylation of Tau protein at Thr212 and shows moderate cytotoxicity in HT22 cells. DYRK2-IN-2 can be used in cancer research.
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- CAS No.: 2416195-65-6
- Formule: C21H24N2O3S
- Masse moléculaire:384.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
DYRK2 40.3 nM (IC50) |
DYRK1A 1842 nM (IC50) |
DYRK1B 1335 nM (IC50) |
DYRK4 1931 nM (IC50) |
DYRK3 112 nM (IC50) |
CLK1 1128 nM (IC50) |
CLK2 4290 nM (IC50) |
CLK3 6496 nM (IC50) |
CLK4 536.9 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HT-22 | IC50 |
14.7 μM
Compound: 37; Cpd C17
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Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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[PMID: 36876904] |
Chemical Information
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CAS No. 2416195-65-6
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Masse moléculaire 384.49
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Formule C21H24N2O3S
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SMILES
COC1=CC2=C(C3=C(C(CO)=CC(OC)=C3)N=C2C=C1)SC[C@H]4CCNC4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DYRK2-IN-2 Related Classifications
HY-402805 Related Classifications
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