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Cat. No.: HY-187844

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FL113

FL113 is a racemate of FL118 (HY-12486). FL113 is less effective than FL118 in inhibiting the expression of Survivin, Mcl-1, XIAP, and cIAP2. FL113 exhibits weaker antitumor activity than FL118 in colon tumor xenograft models. FL113 can be used for research on colon cancer and head and neck cancer.

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CAS No.: 104155-89-7
Formule: C₂₁H₁₆N₂O₆
Masse moléculaire:392.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FL113 Chemical Structure

CAS No.: 104155-89-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

Mcl-1

XIAP

cIAP2

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In Vitro

Anti-cancerApoptosis

Anti-cancer

Apoptosis

FL113 (10 nM; 48-96 h) is far less effective than FL118 (HY-12486) in inhibiting the expression of survivin, Mcl-1, XIAP, and cIAP2 in head and neck FaDu cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

FaDu
Concentration:

10 nM
Incubation Time:

48, 72, and 96 h
Result:

Inhibited survivin, Mcl-1, XIAP, and cIAP2 protein expression less effectively than FL118.

In Vivo

Anti-cancer

FL113 (1.5 mg/kg; i.p.; single injection) is less effective than FL118 in downregulating survivin, Mcl-1, and cIAP2 in mice^[1].
FL113 (1 mg/kg; weekly × 4 schedule) exhibits much weaker antitumor activity than FL118 in colon tumor xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID mice (female, 6-12 weeks old)^[1]
Dosage:

1.5 mg/kg
Administration:

i.p.; single injection
Result:

Resulted in less effective inhibition of survivin, Mcl-1, and cIAP2 expression compared to FL118.
Showed no inhibitory effect on XIAP in the in vivo tumor tissues.

Related Protocols :

Chemical Information

CAS No. 104155-89-7
Masse moléculaire 392.37
Formule C₂₁H₁₆N₂O₆
SMILES

O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=C6OCOC6=CC5=CC4C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhao J, et al. Antitumor activity of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, is highly dependent on its primary structure and steric configuration. Molecular pharmaceutics. 2014 Feb 03;11(2):457-67.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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FL113

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