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Cat. No.: HY-N9488

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Girinimbine

(Synonyms: Girinimbin)

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Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities.

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Pureté: 99.23%
CAS No.: 23095-44-5
Formule: C₁₈H₁₇NO
Masse moléculaire:263.33

Stockage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Girinimbine Chemical Structure

CAS No.: 23095-44-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	>50 μM Compound: Girinimbine	Anticancer activity against human A2780 cells by MTT assay Anticancer activity against human A2780 cells by MTT assay	[PMID: 33316408]
A-431	IC₅₀	>50 μM Compound: Girinimbine	Anticancer activity against human A431 cells by MTT assay Anticancer activity against human A431 cells by MTT assay	[PMID: 33316408]
Bel-7402	IC₅₀	>50 μM Compound: Girinimbine	Anticancer activity against human H7402 cells by MTT assay Anticancer activity against human H7402 cells by MTT assay	[PMID: 33316408]
BGC-823	IC₅₀	>50 μM Compound: Girinimbine	Anticancer activity against human BGC-823 cells by MTT assay Anticancer activity against human BGC-823 cells by MTT assay	[PMID: 33316408]
HCT-8	IC₅₀	34.69 μM Compound: Girinimbine	Anticancer activity against human HCT-8 cells by MTT assay Anticancer activity against human HCT-8 cells by MTT assay	[PMID: 33316408]
HeLa	IC₅₀	>50 μM Compound: Girinimbine	Anticancer activity against human HeLa cells by MTT assay Anticancer activity against human HeLa cells by MTT assay	[PMID: 33316408]
HepG2	IC₅₀	>160 μM Compound: 7	Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay	[PMID: 22093759]
KB	IC₅₀	263.1 μM Compound: 7	Cytotoxicity against human KB cells by resazurin reduction assay Cytotoxicity against human KB cells by resazurin reduction assay	[PMID: 22482432]
KB	IC₅₀	7.02 μM Compound: 5	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 21302964]
KETR3	IC₅₀	>50 μM Compound: Girinimbine	Anticancer activity against human KETR3 cells by MTT assay Anticancer activity against human KETR3 cells by MTT assay	[PMID: 33316408]
MCF7	IC₅₀	28.8 μM Compound: 7	Cytotoxicity against human MCF7 cells by resazurin reduction assay Cytotoxicity against human MCF7 cells by resazurin reduction assay	[PMID: 22482432]
MCF7	IC₅₀	49.76 μM Compound: Girinimbine	Anticancer activity against human MCF7 cells by MTT assay Anticancer activity against human MCF7 cells by MTT assay	[PMID: 33316408]
NCI-H187	IC₅₀	22.37 μM Compound: 5	Cytotoxicity against human NCI-H187 by resazurin microplate assay Cytotoxicity against human NCI-H187 by resazurin microplate assay	[PMID: 21302964]
NCI-H187	IC₅₀	58.9 μM Compound: 7	Cytotoxicity against human NCI-H187 cells by resazurin reduction assay Cytotoxicity against human NCI-H187 cells by resazurin reduction assay	[PMID: 22482432]
NCI-H460	IC₅₀	27.01 μM Compound: Girinimbine	Anticancer activity against human H460 cells by MTT assay Anticancer activity against human H460 cells by MTT assay	[PMID: 33316408]
SW1990	IC₅₀	>50 μM Compound: Girinimbine	Anticancer activity against human SW1990 cells by MTT assay Anticancer activity against human SW1990 cells by MTT assay	[PMID: 33316408]
Vero	IC₅₀	>200 μM Compound: 5	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 21302964]

In Vitro

Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC₅₀ values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells^[1].
Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells^[1]. HepG2 cells^[1].
Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest^[1].
Girinimbine shows a potent antitrypanosomal activitywith an IC₅₀ value of 10.16 µg/mL^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 cells
Concentration:

1 µM, 10 µM, 50 µM, 100 µM, 200 µM
Incubation Time:

24 h, 48 h and 72 h
Result:

Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

56 µM
Incubation Time:

24 h, 48 h
Result:

Showed typical morphological features of apoptosis.

Cell Cycle Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

56 µM
Incubation Time:

12 h, 24 h, 48 h
Result:

Induced G0/G1-phase arrest in HepG2 cells.

In Vivo

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid^[2].
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ICR mice (25-35 g) treated with carrageenan^[2]
Dosage:

10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:

Orally gavage; once
Result:

Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

Chemical Information

CAS No. 23095-44-5
Appearance Solid
Masse moléculaire 263.33
Formule C₁₈H₁₇NO
Color Off-white to light yellow
SMILES

CC(OC1=C(C)C=C23)(C)C=CC1=C3NC4=C2C=CC=C4
Synonyms

Girinimbin
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Suvitha Syam, et al. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011 Aug 23;16(8):7155-70. [Content Brief]

[2]. Venoos Iman, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2016 Dec 28;11:103-121. [Content Brief]

[3]. H O Dyary, et al. Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Trop Biomed. 2019 Mar 1;36(1):94-102. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Girinimbine

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Girinimbine Related Classifications

HY-N9488 Related Classifications