GPI 15427
GPI 15427 is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase-1 (PARP-1), which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion (SAO) shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis, GPI 15427 demonstrates strong anti-inflammatory effects that reduces inflammatory cell infiltration, histological injury. GPI 15427 also diminishes the accumulation of poly (ADP-ribose) in the ileum and colon of treated rats.
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- CAS No.: 805242-85-7
- Formule: C20H20N4O2
- Masse moléculaire:348.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 805242-85-7
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Masse moléculaire 348.40
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Formule C20H20N4O2
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SMILES
O=C1NN=C2C3=C(OC4=CC=C(CN5CCN(C)CC5)C=C42)C=CC=C31
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GPI 15427 Related Classifications
HY-15048 Related Classifications
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