HDAC4-IN-3
HDAC4-IN-3 is a class IIa HDAC4 inhibitor. HDAC4-IN-3 disrupts the HDAC4-JunB transcriptional complex, thereby blocking HDAC4 cooperation with JunB to activate Th17 signature genes, and disrupts HDAC4-JunB interactions in Th17 cells with no detectable effect on HDAC7-Aiolos binding.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C27H25F3N4O3S
- Masse moléculaire:542.57
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
HDAC4 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Th17 cells
-
Concentration:5 μM
-
Incubation Time:24 h
-
Result:Effectively disrupted the HDAC4-JunB interactions in Th17 cells, with activity
comparable to TMP269.
Chemical Information
-
Masse moléculaire 542.57
-
Formule C27H25F3N4O3S
-
SMILES
COC1=CC(C2=CSC(C3(CCOCC3)CNC(C4=CC(C5=CN(C(F)(F)F)N=C5)=CC=C4)=O)=N2)=CC=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC4-IN-3 Related Classifications
HY-189947 Related Classifications
Powered by Bioz