HF50731
Based on 1 Customer Validation
HF50731 (compound 21) is a potent CXCR4 antagonist. HF50731 shows strong CXCR4 binding affinity, with IC50 of 19.8 nM. HF50731 effectively inhibits calcium mobilization, cell migration, and HIV-1 infection via CXCR4 coreceptor, with IC50 values of 119.2 nM, 621.4 nM and 1.5 μM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.66%
- CAS No.: 2484771-19-7
- Formule: C26H46N4
- Masse moléculaire:414.67
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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CXCR4 19.8 nM (IC50) |
HIV-1 1.5 μM (IC50) |
Chemical Information
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CAS No. 2484771-19-7
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Appearance Solid
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Masse moléculaire 414.67
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Formule C26H46N4
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Color White to light yellow
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SMILES
C1(CNCCCNC2CCCCC2)=CC=C(CNCCCNC3CCCCC3)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
In Vitro:
DMSO : 104 mg/mL (250.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Fang X, Meng Q, Zhang H, Liang B, Zhu S, Wang J, Zhang C, Huang LS, Zhang X, Schooley RT, An J, Xu Y, Huang Z. Design, synthesis, and biological characterization of a new class of symmetrical polyamine-based small molecule CXCR4 antagonists. Eur J Med Chem. 2020 Aug 15;200:112410. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4116 mL | 12.0578 mL | 24.1156 mL | 60.2889 mL |
| 5 mM | 0.4823 mL | 2.4116 mL | 4.8231 mL | 12.0578 mL | |
| 10 mM | 0.2412 mL | 1.2058 mL | 2.4116 mL | 6.0289 mL | |
| 15 mM | 0.1608 mL | 0.8039 mL | 1.6077 mL | 4.0193 mL | |
| 20 mM | 0.1206 mL | 0.6029 mL | 1.2058 mL | 3.0144 mL | |
| 25 mM | 0.0965 mL | 0.4823 mL | 0.9646 mL | 2.4116 mL | |
| 30 mM | 0.0804 mL | 0.4019 mL | 0.8039 mL | 2.0096 mL | |
| 40 mM | 0.0603 mL | 0.3014 mL | 0.6029 mL | 1.5072 mL | |
| 50 mM | 0.0482 mL | 0.2412 mL | 0.4823 mL | 1.2058 mL | |
| 60 mM | 0.0402 mL | 0.2010 mL | 0.4019 mL | 1.0048 mL | |
| 80 mM | 0.0301 mL | 0.1507 mL | 0.3014 mL | 0.7536 mL | |
| 100 mM | 0.0241 mL | 0.1206 mL | 0.2412 mL | 0.6029 mL |
HF50731 Related Classifications
HY-146413 Related Classifications
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