IPS-05002
IPS-05002 is an α5β1 antagonist. IPS-05002 can inhibit VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration, and also suppresses tubular network formation. IPS-05002 can upregulate IKB-β, XRCC4, and downregulate Cdc6 in VEGF-induced HUVECs. IPS-05002 can be used for the study of tumor angiogenesis.
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- CAS No.: 1185036-77-4
- Formule: C22H19FN4O2S
- Masse moléculaire:422.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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α5β1 |
IPS-05002 (0.78-200 μM, 1 h) inhibits the binding of integrin α5β1 to fibronectin in a dose-dependent manner[1].
IPS-05002 (72 h) markedly suppresses the proliferation and adhesion of HUVEC (IC50 = 20.5 μM)[1].
IPS-05002 (6.25-1700 μM, 0-24 h) significantly perturbs VEGF-induced HUVEC migration in a dose and time-dependent fashion (IC50 = 15.52 μM)[1].
IPS-05002 (3-50 μM, 90 min) dose-dependently inhibits the adhesion of HUVECs to Matrigel[1].
IPS-05002 (24 h) upregulates VEGF-induced IκB-β and XRCC4 in HUVECs and downregulates Cdc6 protein expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human umbilical vein endothelial cell (HUVEC)
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Concentration:6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM, 106.25 μM, 212.5 μM, 425 μM, 850 μM, 1700 μM
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Incubation Time:0 h, 12 h, 24 h
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Result:Significantly perturbed VEGF-induced HUVEC migration compared with GRGDSP-treated control group in a dose and time-dependent fashion.
Chemical Information
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CAS No. 1185036-77-4
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Masse moléculaire 422.48
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Formule C22H19FN4O2S
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SMILES
OC1=C(C2NCCC3=C2NC4=CC=CC=C43)C(N(C(N1)=S)CC5=CC=C(C=C5)F)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IPS-05002 Related Classifications
HY-118273 Related Classifications
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