Cat. No.: HY-N2381

Menthone

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Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis.

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Pureté: 99.96%
CAS No.: 10458-14-7
Formule: C₁₀H₁₈O
Masse moléculaire:154.25

Stockage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Menthone Chemical Structure

CAS No.: 10458-14-7

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

Schistosome

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In Vitro

Menthone (0.05-500 μM, 48 h) has optimal concentration for murine primary lung mast cells viability are 0.5, 5 and 50 μM^[3].
Menthone (0.5-50 μM, 48 h) inhibits the secretion of proinflammatory cytokine TNF-α and have anti-inflammatory potential to LPS-stimulated lung mast cells^[3].
Menthone (100 μM, 24 h) inhibits activation of the key transcription factor STAT1 of IFN-I signaling and promotes Tyk2 polyubiquitination to reduce Tyk2 protein levels in 2fTGH cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:

2fTGH
Concentration:

100 μM
Incubation Time:

24 h
Result:

Decreased the protein levels of these two ISGs (IFIT1 and PKR) induced by IFN-α.
Reduced the levels of p-STAT1 in the nucleus.
Attenuated menthoneinduced degradation of Tyk2 protein by MG132.
Upregulated K48-linked/K63-linked polyubiquitination of Tyk2.

In Vivo

Menthone (100 mg/kg, Articulus injection, 14 days) inhibits the expression of Th1 and Th17 cells in CIA mouse model^[1].
Menthone (8-200 mg/kg, i.g. , daily, 5 weeks) improves the allergic inflammatory statu of the lungs and airways in OVA-sensitized and challenged allergic asthmatic inflammation mouse model by modulating the Th2-biased immune balance and mitigating mast cell degranulation^[3].
Menthone (100 mg/kg, Articulus injection, 14 days) contributes to the relief of local inflammation of rheumatoid arthritis in CIA mice^[1]^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

OVA-sensitized and challenged allergic asthmatic inflammation mouse model ^[3]
Dosage:

8-200 mg/kg
Administration:

i.g., daily, 5 weeks
Result:

Reversed the allergic inflammation status through at medium and high doses.
Decreased total cell number and eosinophilia into BALF.
Increased the percentage of monocytes/macrophages and Th1 (IL-2+IFN-γ)/Th2 (IL-4+IL-5) cytokine secretion ratio in BALF.
Decreased the levels of otaxin and protein in BALF and reduced the release of β-hexosaminidase from lung mast cells.
Inhibited CC receptor 3 and CXC receptor 1 gene expression levels.

Animal Model:

CIA mouse model^[1]^[4]
Dosage:

100 mg/kg
Administration:

Articulus injection, 14 days
Result:

Decreased degree of posterior palm swelling and alleviated the inflammation in the local knuckles .
Increased the levels of serum Creactive protein (CRP).
Decreased the levels of ISGs (Ifit1, Isg15, and Mx1) and proinflammatory cytokines (TNF-α, IL-6, and IL-1β) in the finger joint tissues of the mice.
Decreased the number of Th1 and Th17 cells.
Decreased the levels of T-bet and RORγT gene transcription and increased the levels of GATA3 and Foxp3.
Didn't produce severe hepatorenal toxicity.

Chemical Information

CAS No. 10458-14-7
Appearance Liquid (Density: 0.896 g/cm³)
Masse moléculaire 154.25
Formule C₁₀H₁₈O
Color Colorless to light yellow
SMILES

O=C1C(C(C)C)CCC(C)C1
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
- Plants
- Labiatae
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (648.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.4830 mL

32.4149 mL

64.8298 mL

5 mM

1.2966 mL

6.4830 mL

12.9660 mL

10 mM

0.6483 mL

3.2415 mL

6.4830 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Chen X, et al. A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro-inflammatory Cytokines of Rheumatoid Arthritis. J Nat Prod. 2022 Apr 22;85(4):1109-1117. [Content Brief]

[2]. Mauricio G Zaia, et al. Anti-Inflammatory Properties of Menthol and Menthone in Schistosoma mansoni Infection. Front Pharmacol. 2016 Jun 17;7:170. [Content Brief]

[3]. Su YH, et al. Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice. Eur J Pharmacol. 2022 Sep 15;931:175222. [Content Brief]

[4]. Chen X, et al. Menthone inhibits type-I interferon signaling by promoting Tyk2 ubiquitination to relieve local inflammation of rheumatoid arthritis. Int Immunopharmacol. 2022 Nov;112:109228. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.4830 mL	32.4149 mL	64.8298 mL	162.0746 mL
	5 mM	1.2966 mL	6.4830 mL	12.9660 mL	32.4149 mL
	10 mM	0.6483 mL	3.2415 mL	6.4830 mL	16.2075 mL
	15 mM	0.4322 mL	2.1610 mL	4.3220 mL	10.8050 mL
	20 mM	0.3241 mL	1.6207 mL	3.2415 mL	8.1037 mL
	25 mM	0.2593 mL	1.2966 mL	2.5932 mL	6.4830 mL
	30 mM	0.2161 mL	1.0805 mL	2.1610 mL	5.4025 mL
	40 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0519 mL
	50 mM	0.1297 mL	0.6483 mL	1.2966 mL	3.2415 mL
	60 mM	0.1080 mL	0.5402 mL	1.0805 mL	2.7012 mL
	80 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	100 mM	0.0648 mL	0.3241 mL	0.6483 mL	1.6207 mL

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Menthone

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Voir tous les produits spécifiques à Isoform NF-κB

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Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Menthone Related Classifications

HY-N2381 Related Classifications