Mesopram
Based on 1 Customer Validation
Mesopram (Daxalipram) is an orally active phosphodiesterase (PDE) 4 inhibitor. Mesopram inhibits the synthesis of proinflammatory cytokines TNF-α and IFN-γ. Mesopram demonstrates efficacy in ameliorating Dextran sulfate sodium (DSS) (HY-116282C)-induced murine colitis. Mesopram can be used for the study of chronic inflammatory diseases.
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- Pureté: 98.80%
- CAS No.: 189940-24-7
- Formule: C14H19NO4
- Masse moléculaire:265.30
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PDE4 |
Mesopram (10 mg/kg, i.p., q.d., 7 days) reduces (Dextran sulfate sodium salt) DSS (HY-116282)-induced colitis in BALB/c mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice[1]
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Dosage:5 mg/kg
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Administration:p.o., once daily, 10 days
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Result:Reduced ethanol intake and preference in male C57BL/6J mice in the 24-h two-bottle choice test.
Decreased ethanol consumption and total fluid intake in male C57BL/6J mice in the 3-h limited access (dark phase) two-bottle choice test.
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Animal Model:DSS-induced colitis preventive model in 6-8-week-old female BALB/c mice[2]
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Dosage:10 mg/kg
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Administration:i.p., q.d., 7 days
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Result:Reduced the clinical score.
Reversed colon shortening.
Lowered ex vivo colonic IFN-γ production.
Chemical Information
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CAS No. 189940-24-7
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Appearance Solid
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Masse moléculaire 265.30
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Formule C14H19NO4
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Color White to off-white
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SMILES
O=C1O[C@](C)(C2=CC=C(OC)C(OCCC)=C2)CN1
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Synonyms
Daxalipram
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Blednov YA, et al. Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129. [Content Brief]
[2]. Loher F, et al. The specific type-4 phosphodiesterase inhibitor mesopram alleviates experimental colitis in mice. J Pharmacol Exp Ther. 2003 May;305(2):549-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mesopram Related Classifications
HY-108622 Related Classifications
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