Remtolumab
Based on 1 Customer Validation
Remtolumab is a bispecific variable domain immunoglobulin molecule with human affinities for TNFα and IL-17 in the low pM range of Kd. Remtolumab can be used in research related to rheumatoid arthritis, psoriatic arthritis, and moderate-to-severe plaque psoriasis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.24%
- CAS No.: 1791410-27-9
- Masse moléculaire:198.31 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
Isotype
[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer
Species Reactivity
Human
IC50 & Target
|
IL-17A |
In Vitro
Remtolumab (ABT-122) is the lead dual variable domain immunoglobul (DVD-Ig™) candidate selected based on its superior affinity and potency targeting human TNF and human IL-17 relative to other top candidates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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[VH-VH'-H-Gamma1_VL-VL'-C-kappa]-dimer
Application
ELISA, FACS, Functional assay
Verified Bioactivity
Chemical Information
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CAS No. 1791410-27-9
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Appearance Liquid
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Masse moléculaire 198.31 kDa
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Color Colorless to light yellow
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SMILES
[Remtolumab]
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Synonyms
ABT-122
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)