(S)-dHTC1
(S)-dHTC1 is a molecular glue degrader targeting the transcriptional co-activator ENL. (S)-dHTC1 binds the ligase with high affinity only after forming the ENL:dHTC1 complex with an IC50 value of 93 nM. (S)-dHTC1 degrades ENL in MV4;11 cells with a DC50 value of 26 nM. (S)-dHTC1 can be used for acute myeloid leukemia study.
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- CAS No.: 3081383-46-9
- Formule: C33H40N8O6S
- Masse moléculaire:676.79
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 3081383-46-9
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Masse moléculaire 676.79
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Formule C33H40N8O6S
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SMILES
O=C(NC1CCC1)C(C=C2)=CN(C2=N3)C=C3C4=CC=CC(C(NCCN5CCC(NS(=O)(N6C[C@@]7(CC(NC7=O)=O)CC6)=O)CC5)=O)=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-dHTC1 Related Classifications
HY-173631 Related Classifications
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