S1g-10
Based on 1 Customer Validation
S1g-10 is a Hsp70/Bim inhibitor, and shows antitumor activity in chronic myeloid leukemia cells.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.08%
- CAS No.: 3032432-71-3
- Formule: C26H31N3OS
- Masse moléculaire:433.61
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Covalent Screening Library
HY-L036
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Cytoskeleton Compound Library
HY-L060
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Anti-Blood Cancer Compound Library
HY-L079
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Mitochondria-Targeted Compound Library
HY-L089
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Metabolic Enzyme Compound Library
HY-L146
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Extracellular Vesicles (EVs) Compound Library
HY-L168
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Anti-Hematopathy Compound Library
HY-L171
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Anti-Ovarian Cancer Compound Library
HY-L173
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Multi-Target Compound Library
HY-L176
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| BV-173 | EC50 |
0.62 μM
Compound: 21; S1g-10
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Induction of apoptosis in human BV-173 cells incubated for 24 hrs by annexin V/PI staining based flow cytometry analysis
Induction of apoptosis in human BV-173 cells incubated for 24 hrs by annexin V/PI staining based flow cytometry analysis
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[PMID: 38011535] |
| BV-173 | EC50 |
0.66 μM
Compound: S1g-10
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Induction of apoptosis in human BV-173 cells incubated for 48 hrs by Annexin V-FITC staining based flow cytometry analysis
Induction of apoptosis in human BV-173 cells incubated for 48 hrs by Annexin V-FITC staining based flow cytometry analysis
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[PMID: 39012838] |
| K562 | EC50 |
1.2 μM
Compound: S1g-10
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Induction of apoptosis in human K562 cells incubated for 48 hrs by Annexin V-FITC staining based flow cytometry analysis
Induction of apoptosis in human K562 cells incubated for 48 hrs by Annexin V-FITC staining based flow cytometry analysis
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[PMID: 39012838] |
| K562 | EC50 |
1.3 μM
Compound: 21; S1g-10
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Induction of apoptosis in human K562 cells incubated for 24 hrs by annexin V/PI staining based flow cytometry analysis
Induction of apoptosis in human K562 cells incubated for 24 hrs by annexin V/PI staining based flow cytometry analysis
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[PMID: 38011535] |
Chemical Information
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CAS No. 3032432-71-3
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Appearance Solid
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Masse moléculaire 433.61
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Formule C26H31N3OS
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Color Light yellow to yellow
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SMILES
O=C1C(C#N)=C(C2=CC=C(C3=C2C1=CC=C3)SC4CCCCC4)NCCN(CC)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 25 mg/mL (57.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (2.31 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (2.31 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3062 mL | 11.5311 mL | 23.0622 mL | 57.6555 mL |
| 5 mM | 0.4612 mL | 2.3062 mL | 4.6124 mL | 11.5311 mL | |
| 10 mM | 0.2306 mL | 1.1531 mL | 2.3062 mL | 5.7655 mL | |
| 15 mM | 0.1537 mL | 0.7687 mL | 1.5375 mL | 3.8437 mL | |
| 20 mM | 0.1153 mL | 0.5766 mL | 1.1531 mL | 2.8828 mL | |
| 25 mM | 0.0922 mL | 0.4612 mL | 0.9225 mL | 2.3062 mL | |
| 30 mM | 0.0769 mL | 0.3844 mL | 0.7687 mL | 1.9218 mL | |
| 40 mM | 0.0577 mL | 0.2883 mL | 0.5766 mL | 1.4414 mL | |
| 50 mM | 0.0461 mL | 0.2306 mL | 0.4612 mL | 1.1531 mL |
S1g-10 Related Classifications
HY-162008 Related Classifications
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