Sulfadimethoxine
Based on 3 publication(s) in Google Scholar
Sulfadimethoxine (Sulphadimethoxine) is an orally active sulfonamide antibiotic. Sulfadimethoxine reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine can be used for the research of avian coccidiosis.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.10%
- CAS No.: 122-11-2
- Formule: C12H14N4O4S
- Masse moléculaire:310.33
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-B0337R
Sulfadimethoxine (Standard)Reference Standard -
HY-B0337B
Sulfadimethoxine 1000 µg/mL in methanolSulfonamide Antibiotic -
HY-B0242
SulfanilamideAntibiotic -
HY-B0035
SulfamethazineSulfonamide Antibiotic -
HY-B0322
SulfamethoxazoleSulfonamide Antibiotic -
HY-B0035R
Sulfamethazine (Standard)Reference Standard -
HY-B0333
SulfamethizoleSulfathiazole Antibiotic -
HY-B0322R
Sulfamethoxazole (Standard)Standard of Sulfamethoxazole -
HY-B0333R
Sulfamethizole (Standard)Antibiotics -
HY-B0242R
Sulfanilamide (Standard)Antibiotic -
HY-B0576
Sulfacetamide sodiumAntibiotic -
HY-B0322B
Sulfamethoxazole 1000 µg/mL in methanolSulfonamide Antibiotic
Publications Citing Use of MedChemExpress (MCE) Sulfadimethoxine
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Activité biologique
Description
IC50 & Target
Antibacterial
In Vitro
Sulfadimethoxine (50 µg/mL; 24 h) exhibits extensive (87.5%) binding to plasma proteins from domestic short-haired cats when tested via equilibrium dialysis at 37°C[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria necatrix-infected chicks, while 0.025% is ineffective against this species[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria acervulina-infected chicks, with 0.05% supporting weight gain equal to uninfected controls[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria maxima-infected chicks, with all doses supporting similar weight gain[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and eliminates pathological lesions in Eimeria brunetti-infected chicks[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria mivati-infected chicks, with 0.05% supporting weight gain greater than uninfected controls[1].
Sulfadimethoxine (0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in chicks with mixed Eimeria infections[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria gallopavonis-infected turkey poults, with 0.025% supporting weight gain greater than uninfected controls[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria meleagrimitis-infected turkey poults[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria adenoeides-infected turkey poults[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Peterson Cross (1 day old, grouped by weight and sex, 2 weeks old at test initiation)[1]
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Dosage:0.025%; 0.05%; 0.1%
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Administration:p.o.; daily; 6 days
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Result:Achieved 0% mortality, 82% weight gain relative to uninfected unmedicated controls (UUC), and average degree of infection (ADI) of 0.3 at 0.1% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.8 at 0.05% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 1.6 at 0.025% dose in Eimeria tenella-infected chicks.
Achieved 0% mortality, 71% weight gain relative to UUC, and ADI of 0.7 at 0.1% dose in Eimeria necatrix-infected chicks.
Achieved 5% mortality, 60% weight gain relative to UUC, and ADI of 1.9 at 0.05% dose in Eimeria necatrix-infected chicks.
Achieved 50% mortality, 39% weight gain relative to UUC, and ADI of 3.4 at 0.025% dose in Eimeria necatrix-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 0.3 at 0.1% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.3 at 0.05% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 92% weight gain relative to UUC, and ADI of 1.6 at 0.025% dose in Eimeria acervulina-infected chicks.
Achieved 0% mortality, 83% weight gain relative to UUC, and ADI of 0.5 at 0.1% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 84% weight gain relative to UUC, and ADI of 0.2 at 0.05% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 84% weight gain relative to UUC, and ADI of 0.4 at 0.025% dose in Eimeria maxima-infected chicks.
Achieved 0% mortality, 80% weight gain relative to UUC, and no detectable lesions at 0.1% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 92% weight gain relative to UUC, and no detectable lesions at 0.05% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 89% weight gain relative to UUC, and no detectable lesions at 0.025% dose in Eimeria brunetti-infected chicks.
Achieved 0% mortality, 86% weight gain relative to UUC, and ADI of 0.0 at 0.1% dose in Eimeria mivati-infected chicks.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria mivati-infected chicks.
Achieved 0% mortality, 102% weight gain relative to UUC, and ADI of 0.4 at 0.025% dose in Eimeria mivati-infected chicks.
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Animal Model:Peterson Cross (1 day old, grouped by weight and sex, 2 weeks old at test initiation)[1]
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Dosage:0.05%
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Administration:p.o.; daily; 6 days
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Result:Achieved 0% mortality, 90% weight gain relative to UUC, and ADI of 0.3 in chicks with mixed Eimeria infections.
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Animal Model:Broad Breasted White (1 day old, grouped by weight and sex, 2 weeks old at test initiation)[1]
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Dosage:0.0125%; 0.025%; 0.05%
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Administration:p.o.; daily; 6 days
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Result:Achieved 0% mortality, 94% weight gain relative to UUC, and ADI of 0.1 at 0.05% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 101% weight gain relative to UUC, and ADI of 0.0 at 0.025% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.1 at 0.0125% dose in Eimeria gallopavonis-infected turkey poults.
Achieved 0% mortality, 77% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 78% weight gain relative to UUC, and ADI of 0.5 at 0.025% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 79% weight gain relative to UUC, and ADI of 0.8 at 0.0125% dose in Eimeria meleagrimitis-infected turkey poults.
Achieved 0% mortality, 89% weight gain relative to UUC, and ADI of 0.0 at 0.05% dose in Eimeria adenoeides-infected turkey poults.
Achieved 0% mortality, 98% weight gain relative to UUC, and ADI of 0.0 at 0.025% dose in Eimeria adenoeides-infected turkey poults.
Achieved 0% mortality, 100% weight gain relative to UUC, and ADI of 0.1 at 0.0125% dose in Eimeria adenoeides-infected turkey poults.
Chemical Information
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CAS No. 122-11-2
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Appearance Solid
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Masse moléculaire 310.33
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Formule C12H14N4O4S
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Color White to off-white
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SMILES
O=S(C1=CC=C(N)C=C1)(NC2=NC(OC)=NC(OC)=C2)=O
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Synonyms
Sulphadimethoxine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Chemosphere
Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters. [Abstract]2019 Jun:225:378-387. PMID: 30884299
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (322.24 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.06 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.06 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (288 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Yang JF, et al. Degradation behavior of sulfadiazine in soils under different conditions. J Environ Sci Health B. 2009 Mar;44(3):241-8. [Content Brief]
[3]. Silva LA, et al. Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol. 2019;202:7-14. [Content Brief]
[4]. Kopmann C, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013;83(1):125-134. [Content Brief]
[6]. Białk-Bielińska A, et al. Sulfadimethoxine and sulfaguanidine: their sorption potential on natural soils. Chemosphere. 2012;86(10):1059-1065. [Content Brief]
[7]. Baggot JD. Pharmacokinetics of sulfadimethoxine in cats. Aust J Exp Biol Med Sci. 1977 Dec;55(6):663-70. [Content Brief]
[8]. Guerard JJ, et al. Photochemical fate of sulfadimethoxine in aquaculture waters. Environ Sci Technol. 2009;43(22):8587-8592. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2224 mL | 16.1119 mL | 32.2238 mL | 80.5594 mL |
| 5 mM | 0.6445 mL | 3.2224 mL | 6.4448 mL | 16.1119 mL | |
| 10 mM | 0.3222 mL | 1.6112 mL | 3.2224 mL | 8.0559 mL | |
| 15 mM | 0.2148 mL | 1.0741 mL | 2.1483 mL | 5.3706 mL | |
| 20 mM | 0.1611 mL | 0.8056 mL | 1.6112 mL | 4.0280 mL | |
| 25 mM | 0.1289 mL | 0.6445 mL | 1.2890 mL | 3.2224 mL | |
| 30 mM | 0.1074 mL | 0.5371 mL | 1.0741 mL | 2.6853 mL | |
| 40 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0140 mL | |
| 50 mM | 0.0644 mL | 0.3222 mL | 0.6445 mL | 1.6112 mL | |
| 60 mM | 0.0537 mL | 0.2685 mL | 0.5371 mL | 1.3427 mL | |
| 80 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0070 mL | |
| 100 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.8056 mL |
Sulfadimethoxine Related Classifications
HY-B0337 Related Classifications
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