CBP/p300 ligand 4
CBP/p300 ligand 4 (Compound 4) is an orally active inhibitor for CBP/p300 bromodomain, with IC50 of 91.4 nM. CBP/p300 ligand 4 serves as a ligand for target protein XYD190 (HY-161495). XYD190 is a PROTAC degrader for CBP/p300.
For research use only. We do not sell to patients.
- CAS No.: 3040120-71-3
- Formula: C30H31F2N5O4
- Molecular Weight:563.60
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
CBP/p300 |
CBP/p300 ligand 4 (0-1 μM, 72-120 h) inhibits proliferations of AML cells MV4;11, MOLM-13 and MOLM-16, with the IC50 of 20.4, 102 and 12.9 nM, respectively, through degradation of CBP, p300 and c-Myc proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MV4;11 AML, MOLM-13 and MOLM-16
-
Concentration:0-1 μM
-
Incubation Time:3 days for MOLM-13, 4 days for MV4;11 AML and MOLM-16
-
Result:Inhibited cell proliferation.
-
Cell Line:MV4;11 AML, MOLM-13 and MOLM-16
-
Concentration:50 nM
-
Incubation Time:24 h
-
Result:Degraded CBP, p300 and c-Myc proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:MV4;11 xenograft NOD-SCID mice model[1]
-
Dosage:10 mg/kg
-
Administration:p.o., once every day for 2 weeks
-
Result:Inhibited tumor growth
Chemical Information
-
CAS No. 3040120-71-3
-
Molecular Weight 563.60
-
Formula C30H31F2N5O4
-
SMILES
O=C1CCC[C@H](N1C2=CC=C(C(F)=C2)F)C3=NC4=C(C=CC(C5=C(ON=C5C)C)=C4)N3C6CCN(CC(O)=O)CC6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz