(5-Cl)-Exatecan
(5-Cl)-Exatecan is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan is applicable for the research of ROR1-positive cancers.
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- CAS. Nr.: 2813268-66-3
- Formel: C24H22ClN3O4
- Molecular Weight:451.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Camptothecins |
Chemical Information
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CAS. Nr. 2813268-66-3
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Molecular Weight 451.90
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Formel C24H22ClN3O4
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SMILES
N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(Cl)=C(C)C(CC1)=C62
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
DMSO : ≥ 50 mg/mL (110.64 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2129 mL | 11.0644 mL | 22.1288 mL | 55.3220 mL |
| 5 mM | 0.4426 mL | 2.2129 mL | 4.4258 mL | 11.0644 mL | |
| 10 mM | 0.2213 mL | 1.1064 mL | 2.2129 mL | 5.5322 mL | |
| 15 mM | 0.1475 mL | 0.7376 mL | 1.4753 mL | 3.6881 mL | |
| 20 mM | 0.1106 mL | 0.5532 mL | 1.1064 mL | 2.7661 mL | |
| 25 mM | 0.0885 mL | 0.4426 mL | 0.8852 mL | 2.2129 mL | |
| 30 mM | 0.0738 mL | 0.3688 mL | 0.7376 mL | 1.8441 mL | |
| 40 mM | 0.0553 mL | 0.2766 mL | 0.5532 mL | 1.3830 mL | |
| 50 mM | 0.0443 mL | 0.2213 mL | 0.4426 mL | 1.1064 mL | |
| 60 mM | 0.0369 mL | 0.1844 mL | 0.3688 mL | 0.9220 mL | |
| 80 mM | 0.0277 mL | 0.1383 mL | 0.2766 mL | 0.6915 mL | |
| 100 mM | 0.0221 mL | 0.1106 mL | 0.2213 mL | 0.5532 mL |
(5-Cl)-Exatecan Related Classifications
HY-160806 Related Classifications
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