Umbralisib R-enantiomer
Based on 1 Customer Validation
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is a PI3Kδ inhibitor, which is the less active enantiomer of TGR-1202.
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- Reinheit: 99.52%
- CAS. Nr.: 1532533-69-9
- Formel: C31H24F3N5O3
- Molecular Weight:571.55
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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PI3Kδ |
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) (Formula A) exhibits a 50% inhibitory concentration (IC50) with respect to the δ type PI3-kinase that is at least 20-fold lower than the inhibitor's IC50 with respect to the rest of the other PI3K isoforms (i.e., a, β, and γ)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1532533-69-9
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Appearance Solid
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Molecular Weight 571.55
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Formel C31H24F3N5O3
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Color White to light yellow
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SMILES
O=C1C(C2=CC=CC(F)=C2)=C([C@@H](C)N3N=C(C4=CC=C(OC(C)C)C(F)=C4)C5=C(N)N=CN=C53)OC6=CC=C(F)C=C16
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Synonyms
TGR-1202 R-enantiomer; RP5264 R-enantiomer
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
DMSO : 33.33 mg/mL (58.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7496 mL | 8.7481 mL | 17.4963 mL | 43.7407 mL |
| 5 mM | 0.3499 mL | 1.7496 mL | 3.4993 mL | 8.7481 mL | |
| 10 mM | 0.1750 mL | 0.8748 mL | 1.7496 mL | 4.3741 mL | |
| 15 mM | 0.1166 mL | 0.5832 mL | 1.1664 mL | 2.9160 mL | |
| 20 mM | 0.0875 mL | 0.4374 mL | 0.8748 mL | 2.1870 mL | |
| 25 mM | 0.0700 mL | 0.3499 mL | 0.6999 mL | 1.7496 mL | |
| 30 mM | 0.0583 mL | 0.2916 mL | 0.5832 mL | 1.4580 mL | |
| 40 mM | 0.0437 mL | 0.2187 mL | 0.4374 mL | 1.0935 mL | |
| 50 mM | 0.0350 mL | 0.1750 mL | 0.3499 mL | 0.8748 mL |
Umbralisib R-enantiomer Related Classifications
HY-12279F Related Classifications
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