AM12
AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.
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- CAS. Nr.: 2387510-84-9
- Formel: C15H9BrO5
- Molecular Weight:349.13
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
IC50: 0.28 μM (TRPC5)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.28 μM
Compound: 20; AM12
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Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fura-2 dye based fluorescence assay
Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in gadolinium-induced calcium entry after 30 mins by fura-2 dye based fluorescence assay
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[PMID: 30943030] |
AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A[1].
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it[1].
AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2387510-84-9
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Molecular Weight 349.13
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Formel C15H9BrO5
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SMILES
O=C1C(O)=C(C2=CC=CC=C2Br)OC3=C1C(O)=CC(O)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AM12 Related Classifications
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