Bcl-2-IN-7
Bcl-2-IN-7 (compound 6) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC50 values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively.
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- CAS. Nr.: 3027734-46-6
- Formel: C24H22N4O5S2
- Molecular Weight:510.59
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Bcl-2 |
Bax |
Caspase-7 |
Chemical Information
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CAS. Nr. 3027734-46-6
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Molecular Weight 510.59
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Formel C24H22N4O5S2
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SMILES
O=C(NC1=CC=CC=C1C)CSC(N2C3=CC=C(S(=O)(N)=O)C=C3)=NC4=C(C=CC=C4OC)C2=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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