Clozapine-d11
Clozapine-d11 (HF 1854-d11) is the deuterium labeled Clozapine (HY-14539). Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50 = 11 nM).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1233341-42-8
- Formel: C18H8D11ClN4
- Molecular Weight:337.89
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1233341-42-8
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Unlabeled Cas 5786-21-0
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Molecular Weight 337.89
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Formel C18H8D11ClN4
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SMILES
ClC1=CC=C2NC3=CC=CC=C3C(N(C([2H])([2H])C4([2H])[2H])C([2H])([2H])C([2H])([2H])N4C([2H])([2H])[2H])=NC2=C1
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Synonyms
HF 1854-d11; ZINC000019796155-d11
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Clozapine-d11 Related Classifications
HY-14539S5 Related Classifications
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