EZH2-IN-19
EZH2-IN-19 (conpound N40) is a potent inhibitor of enhancer of zeste homolog 2 (EZH2) WT, with the IC50 of 0.32 nM. EZH2-IN-19 plays an important role in cancer research.
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- CAS. Nr.: 3026848-13-2
- Formel: C40H55N7O3
- Molecular Weight:681.91
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
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EZH2 WT 0.32 nM (IC50) |
EZH2 Y641F mutant type 0.03 nM (IC50) |
EZH2 Y641N 0.08 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| KARPAS-422 | IC50 |
3.52 nM
Compound: N40
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Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 method
Antiproliferative activity against human KARPAS-422 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 method
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[PMID: 38640588] |
Chemical Information
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CAS. Nr. 3026848-13-2
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Molecular Weight 681.91
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Formel C40H55N7O3
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SMILES
CCN(C1CCC(CC1)N(C)C)C2=CC(C3=CC=C4C(N(C(N4C5CCN(C)CC5)=O)C)=C3)=CC(C(NCC6=C(C=C(NC6=O)C)C)=O)=C2C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EZH2-IN-19 Related Classifications
HY-163741 Related Classifications
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