Fibrostat
Based on 1 publication(s) in Google Scholar
Fibrostat (Compound 5n) is a selective HDAC6 inhibitor that exerts antifibrotic effects by inhibiting HDAC6 activity, with an IC50 value of 63 nM. It also exhibits good selectivity over HDAC1, HDAC3, HDAC5, HDAC8, HDAC10, and HDAC11. Fibrostat significantly downregulates fibrotic markers (fibronectin and collagen 1) in fibroblasts. Additionally, Fibrostat demonstrated no toxicity in rat-perfused heart and zebrafish larvae models. Fibrostat shows potential for research into fibrosis-related diseases.
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- Formel: C29H32N4O3
- Molecular Weight:484.59
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Speicherung:
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Biologische Aktivität
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HDAC6 63 nM (IC50) |
Chemical Information
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Molecular Weight 484.59
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Formel C29H32N4O3
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SMILES
O=C(N1CCC2(CC3=CC=CC=C3CN2CC4=CC=CC=C4)CC1)NCC5=CC=C(C=C5)C(NO)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Fibrostat Related Classifications
HY-169940 Related Classifications
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