BECN1 - beclin 1 Gene

Also Known as ATG6; VPS30; beclin1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8678

About BECN1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:42,810,132-42,824,282 (from NCBI)

This gene has 22 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 32.3), duodenum (RPKM 27.0) and 25 other tissues.

Summary

This gene encodes a protein that regulates Autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

BECN1 Products (8)

mRNA	Protein	Name
NM_001313998.2	NP_001300927.1	beclin-1 isoform a
NM_001314000.2	NP_001300929.1	beclin-1 isoform c
NM_003766.5	NP_003757.1	beclin-1 isoform a
XM_005257759.4	XP_005257816.1	beclin-1 isoform X1
XM_017025263.3	XP_016880752.1	beclin-1 isoform X1
XM_005257760.5	XP_005257817.1	beclin-1 isoform X2
NM_001313999.1	NP_001300928.1	beclin-1 isoform b
XM_017025264.3	XP_016880753.1	beclin-1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	25891078	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	34796041	GOA
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	23878393	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16417406	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	27853422	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	25891078	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	25127057	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	25891078	GOA
involved in autophagosome maturation	IDA IDA: Inferred from direct assay	10625637	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	23629966	GOA
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	28747345	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	23184933	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	34796041	GOA
involved in early endosome to late endosome transport	IDA IDA: Inferred from direct assay	14617358	GOA
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	26783301	GOA
involved in mitophagy	IMP IMP: Inferred from mutant phenotype	23878393	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	23478334	GOA
acts upstream of or within negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	19273585	GOA
involved in phosphatidylinositol-3-phosphate biosynthetic process	IDA IDA: Inferred from direct assay	8999962	GOA
involved in positive regulation of attachment of mitotic spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	23478334	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	21358617	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	27031958	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	25891078	GOA
involved in receptor catabolic process	IMP IMP: Inferred from mutant phenotype	20643123	GOA
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	16799551	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	20208530	GOA
involved in regulation of macroautophagy	IDA IDA: Inferred from direct assay	10625637	GOA
involved in response to mitochondrial depolarisation	IMP IMP: Inferred from mutant phenotype	23878393	GOA
involved in suppression by virus of host autophagy	IDA IDA: Inferred from direct assay	18797192	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22498477	GOA
located in cytoplasmic side of mitochondrial outer membrane	IDA IDA: Inferred from direct assay	23878393	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23878393	GOA
located in endosome	IDA IDA: Inferred from direct assay	23878393	GOA
colocalizes with mitochondrion	IMP IMP: Inferred from mutant phenotype	23878393	GOA
part of phosphatidylinositol 3-kinase complex, class III	IPI IPI: Inferred from physical interaction	25490155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BECN1 Protein Structure

BH3

APG6

0
100
200
300
400
450 a.a.

Protein Preferred Names	Protein Names
beclin-1	ATG6 autophagy related 6 homolog beclin 1 (coiled-coil, moesin-like BCL2-interacting protein) beclin 1, autophagy related beclin1-beta beclin1-gamma coiled-coil myosin-like BCL2-interacting protein testis secretory sperm-binding protein Li 215e

BECN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BECN1	Q14457	ZWINT	Homo sapiens	O95229	IF	23478334
Intra	BECN1	Q14457	ZWINT	Homo sapiens	O95229	Anti Bait CoIP	23478334
Intra	BECN1	Q14457	ZWINT	Homo sapiens	O95229	Anti Tag CoIP	20562859
Intra	BECN1	Q14457	MCL1	Homo sapiens	Q07820	Anti Bait CoIP	21139567
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	20562859
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	19050071
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	26496610
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	GMS	24056303
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	24034250
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	23316280
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	26783301
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	24472739
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	25594178
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	EM	25490155
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	23364696
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	23954414
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Bait CoIP	23316280
Intra	BECN1	Q14457	PIK3C3	Homo sapiens	Q8NEB9	Anti Tag CoIP	24034250
Intra	BECN1	Q14457	AMBRA1	Homo sapiens	Q9C0C7	Anti Tag CoIP	20562859
Intra	BECN1	Q14457	AMBRA1	Homo sapiens	Q9C0C7	Anti Bait CoIP	23974797
Intra	BECN1	Q14457	AMBRA1	Homo sapiens	Q9C0C7	Anti Tag CoIP	23954414
Cross	BECN1	Q14457	P0C6X5-PRO_0000283876	Human coronavirus NL63	P0C6X5-PRO_0000283876	Anti Tag CoIP	25311841
Intra	BECN1	Q14457	VMP1	Homo sapiens	Q96GC9	Anti Bait CoIP	23316280
Intra	BECN1	Q14457	BCL2L1	Homo sapiens	Q07817-1	Y2H	17446862
Intra	BECN1	Q14457	BCL2L1	Homo sapiens	Q07817-1	Anti Tag CoIP	17446862
Intra	BECN1	Q14457	BCL2L1	Homo sapiens	Q07817-1	FPS	17446862
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	EM	25490155
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	26496610
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Validated Y2H	32296183
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	GMS	24056303
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	35271311
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Anti Bait CoIP	24034250
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Pull Down	19050071
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	23954414
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	19050071
Intra	BECN1	Q14457	UVRAG	Homo sapiens	Q9P2Y5	Anti Tag CoIP	20562859
Intra	BECN1	Q14457	RUBCN	Homo sapiens	Q92622	Anti Bait CoIP	24034250
Intra	BECN1	Q14457	RUBCN	Homo sapiens	Q92622	Anti Bait CoIP	25594178
Intra	BECN1	Q14457	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	24034250
Intra	BECN1	Q14457	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	23954414
Intra	BECN1	Q14457	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	20562859
Intra	BECN1	Q14457	RUBCN	Homo sapiens	Q92622	Anti Tag CoIP	22493499
Intra	BECN1	Q14457	EGFR	Homo sapiens	P00533	Anti Bait CoIP	24034250
Intra	BECN1	Q14457	EGFR	Homo sapiens	P00533	Anti Tag CoIP	24034250
Intra	BECN1	Q14457	EGFR	Homo sapiens	P00533	IF	24034250
Intra	BECN1	Q14457	KRT18	Homo sapiens	P05783	Anti Bait CoIP	23112296
Intra	BECN1	Q14457	KRT18	Homo sapiens	P05783	Anti Tag CoIP	23112296
Intra	BECN1	Q14457	RAB39A	Homo sapiens	Q14964	Anti Bait CoIP	24349490
Intra	BECN1	Q14457	VIM	Homo sapiens	P08670	Anti Tag CoIP	23112296
Intra	BECN1	Q14457	DAPK1	Homo sapiens	P53355	Pull Down	19180116
Intra	BECN1	Q14457	DAPK1	Homo sapiens	P53355	Anti Tag CoIP	19180116
Intra	BECN1	Q14457	TAB2	Homo sapiens	Q9NYJ8	Y2H	22081109
Intra	BECN1	Q14457	TAB2	Homo sapiens	Q9NYJ8	Pull Down	22081109
Intra	BECN1	Q14457	TAB2	Homo sapiens	Q9NYJ8	Anti Tag CoIP	22081109
Intra	BECN1	Q14457	TAB2	Homo sapiens	Q9NYJ8	Anti Bait CoIP	22081109
Intra	BECN1	Q14457	TAB3	Homo sapiens	Q8N5C8	Pull Down	22081109
Intra	BECN1	Q14457	TAB3	Homo sapiens	Q8N5C8	Anti Tag CoIP	22081109
Intra	BECN1	Q14457	TAB3	Homo sapiens	Q8N5C8	Anti Bait CoIP	22081109
Intra	BECN1	Q14457	TAB3	Homo sapiens	Q8N5C8	Y2H	22081109
Intra	BECN1	Q14457	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	BECN1	Q14457	GRB2	Homo sapiens	P62993	Anti Bait CoIP	38182563
Intra	BECN1	Q14457	GRB2	Homo sapiens	P62993	Anti Tag CoIP	38182563
Intra	BECN1	Q14457	HTT	Homo sapiens	P42858	Anti Bait CoIP	28445460
Intra	BECN1	Q14457	HTT	Homo sapiens	P42858	BioID	34524948
Intra	BECN1	Q14457	WASHC1	Homo sapiens	A8K0Z3	IF	23974797
Intra	BECN1	Q14457	WASHC1	Homo sapiens	A8K0Z3	Anti Bait CoIP	23974797
Intra	BECN1	Q14457	EXOC8	Homo sapiens	Q8IYI6	IF	21241894
Intra	BECN1	Q14457	SGF29	Homo sapiens	Q96ES7	Validated Y2H	32296183
Intra	BECN1	Q14457	BCL2	Homo sapiens	P10415	Anti Bait CoIP	24034250
Intra	BECN1	Q14457	BCL2	Homo sapiens	P10415	Anti Bait CoIP	23541952
Intra	BECN1	Q14457	BCL2	Homo sapiens	P10415	Anti Bait CoIP	24472739
Intra	BECN1	Q14457	BCL2	Homo sapiens	P10415	Pull Down	19180116
Intra	BECN1	Q14457	BCL2	Homo sapiens	P10415	Anti Tag CoIP	23954414
Intra	BECN1	Q14457	BCL2	Homo sapiens	P10415	Anti Tag CoIP	21358617
Intra	BECN1	Q14457	BCL2	Homo sapiens	P10415	Anti Tag CoIP	19050071
Intra	BECN1	Q14457	BCL2L1	Homo sapiens	Q07817	Anti Tag CoIP	19180116
Cross	BECN1	Q14457	Slamf1	Mus musculus	Q9QUM4	Anti Bait CoIP	22493499
Intra	BECN1	Q14457	ATXN3	Homo sapiens	P54252-1	Anti Bait CoIP	28445460
Cross	BECN1	Q14457	Vmp1	Rattus norvegicus	Q91ZQ0	Anti Tag CoIP	23316280
Cross	BECN1	Q14457	Vmp1	Rattus norvegicus	Q91ZQ0	IF	23316280
Cross	BECN1	Q14457	nef	Human immunodeficiency virus	P03407	Anti Tag CoIP	23364696
Cross	BECN1	Q14457	vBCL2	Murid herpesvirus 4	P89884	Y2H Array	22028648
Cross	BECN1	Q14457	vBCL2	Murid herpesvirus 4	P89884	ITC	24443581
Cross	BECN1	Q14457	vBCL2	Murid herpesvirus 4	P89884	Anti Tag CoIP	24034250

Cross: Cross-species interaction Intra: Intraspecies interaction

BECN1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80568	Beclin 1 Antibody (YA587)	WB, IP	Human, Mouse, Rat
HY-P80568A	Beclin 1 Antibody (YA587)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P810545	Phospho-Beclin 1 (Ser30) Antibody (YA9814)	WB	Human, Mouse, Rat
HY-P84570	Beclin 1 Antibody (YA4267)	WB, IHC-P, FC, ELISA	Human
HY-P84570A	Beclin 1 Antibody (YA4267)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P86374	Beclin 1 Antibody (YA6066)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86676	Beclin 1 Antibody (YA6368)	IHC-P, WB, IF-Tissue, IHC-F	Human, Mouse, Rat
HY-P86676A	Beclin 1 Antibody (YA6368)(PBS only)	IHC-P, WB, IF-Tissue, IHC-F	Human, Mouse, Rat
HY-P86741	Beclin 1 Antibody (YA6433)	IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
HY-P86741A	Beclin 1 Antibody (YA6433)(PBS only)	IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Myopathy, X-Linked, With Excessive Autophagy	X-Linked Myopathy With Excessive Autophagy Xmea MEAX Vacuolar Myopathy
Glottis Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Glottis Squamous Cell Carcinoma Of Glottis
Danon Disease	Pseudoglycogenosis Ii Antopol Disease Glycogen Storage Disease Iib Glycogen Storage Disease Type 2b Glycogen Storage Disease Type Iib Gsd2b Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency Vacuolar Cardiomyopathy And Myopathy X-Linked Vacuolar Cardiomyopathy And Myopathy, X-Linked Lysosomal Glycogen Storage Disease Without Acid Maltase Deficiency, Formerly Gsd2b, Formerly Gsd Iib, Formerly Glycogen Storage Cardiomyopathy Glycogen Storage Disease Limited To The Heart Pseudoglycogenosis 2 X-Linked Vacuolar Cardiomyopathy And Myopathy Lysosomal Glycogen Storage Disease With Normal Acid Maltase Glycogen Storage Disease Due To Lamp-2 Deficiency Gsd Due To Lamp-2 Deficiency Glycogenosis Due To Lamp-2 Deficiency Lysosomal Glycogen Storage Disease With Normal Acid Maltase Activity DAND Gsd-Iib
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Wolfram Syndrome 2	WFS2
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Macular Degeneration, Age-Related, 14	Age Related Macular Degeneration 14 ARMD14 Macular Degeneration, Age-Related, 14, Reduced Risk Of Macular Degeneration, Age-Related, Type 14
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Sphingolipidosis	Sphingolipidoses
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Cystinosis	Cystine Storage Disease Cystine Diathesis Cystine Disease Cystinoses Protein Defect Of Cystin Transport Cystin Transport, Protein Defect Of Nephropathic Cystinosis Protein Defect Of Cystine Transport
Leukodystrophy, Hypomyelinating, 12	Hypomyelinating Leukodystrophy 12 HLD12 Vps11-Related Autosomal Recessive Hypomyelinating Leukodystrophy Vps11-Related Autosomal Recessive Hypomyelinating Leukoencephalopathy
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Mouth Disease	Mouth Diseases Mouth Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-137506	XST-14		99.26%	Unkown
HY-N1956	Rubiadin-1-methyl ether	Inhibitor	98.57%	Unkown
HY-149954	SARS-CoV-2-IN-39	Inhibitor	99.79%	Unkown
HY-RS01463	BECN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01464	Becn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01465	Becn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BECN1	VGNC	VGNC:70044
Mus musculus	BECN1	MGD	MGI:1891828
Rattus norvegicus	BECN1	RGD	RGD:620190
Bos taurus	BECN1	VGNC	VGNC:26463
Felis catus	BECN1	VGNC	VGNC:60099
Others	BECN1	NCBI