IBG3
Based on 1 publication(s) in Google Scholar
IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC50 values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.53%
- Formel: C54H57N9O5S2
- Molecular Weight:976.22
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Epigenetics Compound Library
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Histone Modification Research Compound Library
HY-L024
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HY-L039
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HY-L171
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Publications Citing Use of MedChemExpress (MCE) IBG3
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Biologische Aktivität
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BRD2 8.6 pM (DC50) |
BRD4 6.7 pM (DC50) |
IBG3 (6 h) potently degrades BRD4Tandem in KBM7 cells, with a DC50 value of 6.7 pM, which is more potent than IBG1 and dBET6[1].
IBG3 (1 nM-10 μM; 30 min) promotes the formation of the BRD4-DCAF16 ternary complex in vitro, with an EC50 of 32 nM, and exhibits stronger complex-stabilizing activity compared with IBG1[1].
IBG3 (1 pM-100 μM; 5 h) potently degrades BRD2 (DC50 = 8.6 pM) and BRD4 in HEK293 HiBiT knock-in cells, but shows no effect on BRD3, with higher efficiency than IBG1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 976.22
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Formel C54H57N9O5S2
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Color Off-white to light yellow
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SMILES
O=C(NCC1=CC=C(C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4)C=C1)C5=CC=C(C6=CC=C(C7=N[C@@H](CC(OC(C)(C)C)=O)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Structure
CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1. [Abstract]2026 Mar 20:S0969-2126(26)00056-0. PMID: 41864201
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (102.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.0244 mL | 5.1218 mL | 10.2436 mL | 25.6090 mL |
| 5 mM | 0.2049 mL | 1.0244 mL | 2.0487 mL | 5.1218 mL | |
| 10 mM | 0.1024 mL | 0.5122 mL | 1.0244 mL | 2.5609 mL | |
| 15 mM | 0.0683 mL | 0.3415 mL | 0.6829 mL | 1.7073 mL | |
| 20 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2804 mL | |
| 25 mM | 0.0410 mL | 0.2049 mL | 0.4097 mL | 1.0244 mL | |
| 30 mM | 0.0341 mL | 0.1707 mL | 0.3415 mL | 0.8536 mL | |
| 40 mM | 0.0256 mL | 0.1280 mL | 0.2561 mL | 0.6402 mL | |
| 50 mM | 0.0205 mL | 0.1024 mL | 0.2049 mL | 0.5122 mL | |
| 60 mM | 0.0171 mL | 0.0854 mL | 0.1707 mL | 0.4268 mL | |
| 80 mM | 0.0128 mL | 0.0640 mL | 0.1280 mL | 0.3201 mL | |
| 100 mM | 0.0102 mL | 0.0512 mL | 0.1024 mL | 0.2561 mL |
IBG3 Related Classifications
HY-160528 Related Classifications
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