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Art. -Nr.: HY-122241

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MT477

MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity.

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CAS. Nr.: 328069-91-6
Formel: C₃₁H₃₀N₂O₁₂S₃
Molecular Weight:718.77

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

MT477 Chemical Structure

CAS. Nr.: 328069-91-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle PKC Isoform-spezifische Produkte anzeigen :

In Vitro

MT477 (0.05 mM; 1, 24 h) induces apoptosis and necrosis in a time-dependent manner^[1].
MT477 (0.05 mM; 0.5, 1, 2, 4 h) decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MCF-7, U87, H226, LNCaP, A549, A431 cells
Concentration:

0.001-1 mM
Incubation Time:

1 h
Result:

Showed antiproliferative activity with IC₅₀s of 0.018, 0.051, 0.013, 0.033, 0.020, 0.049 mM for MCF-7, U87, H226, LNCaP, A549, A431 cells, respectively.

Western Blot Analysis^[1]

Cell Line:

H266 cells
Concentration:

0.05 mM
Incubation Time:

0.5, 1, 2, 4 h
Result:

Decreased the protein expression of Ras-GTP, p-Erk1/2, p-Elk1 in a time-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

H266 cells
Concentration:

0.05 mM
Incubation Time:

1, 24 h
Result:

Induced apoptosia with the percentage of cells underwent apoptosis after 1 h of treatment of 18.6 and after 24 h of treatment of 98%.

In Vivo

MT477 (33, 100, 1000 µg/kg; i.p.; once a day on days 1, 4, 8, 16, 18, 20) shows antitumor activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-week-old male nude mice (A431 cells) ^[1]
Dosage:

33, 100, 1000 µg/kg
Administration:

I.p.; once a day on days 1, 4, 8, 16, 18, 20
Result:

Significant decreased in tumor volume of 24.5% by the third week at 1 mg/kg.

Animal Model:

6-week-old male nude mice (H226 cells) ^[1]
Dosage:

1 mg/kg
Administration:

I.p.; once a day on days 1, 4, 8, 20, 24, 28
Result:

Inhibited tumor growth by 43.6% and observed no weight loss.

Chemical Information

CAS. Nr. 328069-91-6
Molecular Weight 718.77
Formel C₃₁H₃₀N₂O₁₂S₃
SMILES

O=C(OC)C1=C(SC2=C(C3=C(C(OC)=CC=C3)N(C2(C)C)C(CN4C(CCC4=O)=O)=O)C15SC(C(OC)=O)=C(S5)C(OC)=O)C(OC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jasinski P, et al. A novel quinoline, MT477: suppresses cell signaling through Ras molecular pathway, inhibits PKC activity, and demonstrates in vivo anti-tumor activity against human carcinoma cell lines. Invest New Drugs. 2008 Jun;26(3):223-32. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
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- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
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MT477

Alle PKC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MT477 Related Classifications

HY-122241 Related Classifications