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Art. -Nr.: HY-183734

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Obuprazine

Obuprazine is an orally active dopamine D3 receptor agonist and 5-HT2A receptor antagonist with IC₅₀ values of 0.37 and 4.19 nM, respectively. Obuprazine acts as a G protein-coupled receptor modulater. Obuprazine can be used for the research of schizophrenia.

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CAS. Nr.: 2640663-79-0
Formel: C₂₀H₂₄Cl₂N₄O₂
Molecular Weight:423.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Obuprazine Chemical Structure

CAS. Nr.: 2640663-79-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

D₃ Receptor

0.37 nM (IC₅₀)

5-HT_2A Receptor

4.19 nM (IC₅₀)

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Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Obuprazine acts as a potent agonist in cells stably expressing the dopamine D3 receptor, reducing cAMP levels with an EC₅₀ of 0.6 nM^[1].
Obuprazine potently inhibits 5-HT2A receptor-mediated calcium flux in stably expressing cells with an IC₅₀ of 2.21 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-t	AUC_0-∞	T_1/2	MRT
Mice^[1]	5 mg/kg	p.o.	0.5 h	673.0 ng/mL	1844.0 ng·h/mL	1970.0 ng·h/mL	1.9 h	3.1 h

In Vivo

Obuprazine (1 mg/kg; p.o.; single dose) exhibits antipsychotic effect on rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male F344 rats (6-8 weeks) with schizophrenia^[1]
Dosage:

1 mg/kg
Administration:

p.o.; single dose
Result:

Exhibited an avoidance response inhibition rate (CAR value) of 18.5%.
Showed antipsychotic effect on rats.

Chemical Information

CAS. Nr. 2640663-79-0
Molecular Weight 423.34
Formel C₂₀H₂₄Cl₂N₄O₂
SMILES

ClC1=C(C=CC=C1Cl)N2CCN(CC2)CC[C@H]3C[C@@H](C3)NC(C4=NC=CO4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chen JY, et al. Salt containing piperazine polycyclic derivative, crystal form thereof, preparation method therefor, and use thereof. WO2022228447A1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Obuprazine

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen