Peptide R54
Peptide R54 (Pep R54; CXCR4 antagonist peptide 19) is an antagonistic peptide targeting CXCR4 with significant anticancer activity. Peptide R54 inhibits CXCR4-dependent cell migration, epithelial-mesenchymal transition, and lung metastasis development, with better serum stability and higher CXCR4 affinity than the lead compound (IC50=20 nM). Peptide R54 synergizes with anti-PD-1 therapy to exert anti-tumor activity in vivo, enhances granzyme activity, and reduces infiltration of Foxp3 cells. Peptide R54 can be used in the study of colon cancer, ovarian cancer, and melanoma.
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- CAS. Nr.: 2232233-39-3
- Formel: C44H63N15O9S2
- Molecular Weight:1010.20
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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CXCR4 |
Chemical Information
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CAS. Nr. 2232233-39-3
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Molecular Weight 1010.20
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Formel C44H63N15O9S2
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Synonyms
Pep R54; CXCR4 antagonist peptide 19
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Sequence
Ac-Arg-Ala-cyclo{{d-Cys}-Arg-2-Nal-His-Pen}
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Sequence Shortening
Ac-RA-cyclo{{d-C}R-2-Nal-H-Pen}
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. D'Alterio C, et al. Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1. J Exp Clin Cancer Res. 2019 Oct 28;38(1):432. [Content Brief]
[2]. Russo D, et al. The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells. PLoS One. 2024 Dec 19;19(12):e0314735. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Peptide R54 Related Classifications
HY-P11011 Related Classifications
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